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Status unknownNCT00629668Updated Mar 6, 2008

Genetic Polymorphisms of TNF-α Promoter and HBV Genotype on Outcome of HBV-Related Chronic Liver Disease

An interventional study of TNF-alpha and HBV genotype and TNF-alpha and HBV genotypes in Chronic Liver Disease and Hepatocellular Carcinoma, sponsored by Kaohsiung Medical University Chung-Ho Memorial Hospital. Status unknown at 1 site in Taiwan. Per ClinicalTrials.gov, last updated 2008-03-06.

Sponsored by Kaohsiung Medical University Chung-Ho Memorial Hospital · Not applicable, Interventional, and Basic science

The sponsor has not verified this record recently (last verified Jul 2007), so the status shown — last known as Recruiting — may be out of date.
Phase
Not applicable
Study type
Interventional
Allocation
Randomized
Sex
All
01

Study summary

The prognosis of Hepatitis B virus (HBV)infection varies from minimal progressive liver disease to cirrhosis or hepatocellular carcinoma (HCC).Both viral and host genetic factors contribute to disease severity. Cytokine gene polymorphism has been regarded affecting prognosis of disease. By detecting HBV genotyping and tumor necrosis factor-alpha polymorphism, this study aime to assess their effects and interaction on disease severity of HBV-related chronic liver disease and HCC.

02

Conditions studied

  • Chronic Liver Disease
  • Hepatocellular Carcinoma

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03

In context

Liver Diseases

2,081 studies on the registry are indexed under Liver Diseases; 390 are open to participants now.

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Lead sponsor

Kaohsiung Medical University Chung-Ho Memorial Hospital is the lead sponsor of 281 studies on the registry; 57 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • HBV-positive patients

Exclusion criteria

Exclusion Criteria:

  • HBV-negative patients
05

Study design

Phase
Not applicable
Primary purpose
Basic science
Allocation
Randomized
Intervention model
Single group
Masking
None (open label)

Interventions

  • GeneticTNF-alpha and HBV genotype
  • OtherTNF-alpha and HBV genotypes
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What researchers measure

Primary outcomes

  1. cytokine gene polymorphism

    Time frame: years

Secondary outcomes

  1. cytokine gene polymorohism on severity of disease

    Time frame: years

07

Study locations

1 of 1 sites recruiting
  • Kaohsiung Medical University Chung-Ho Memorial Hospital
    Kaohsiung, 807, Taiwan
    • Jen-Eing Jeng, M.D. · Contact · jejeng @cc.kmu.edu.tw · 886-7-3121101
    • Jen-Eing Jeng, M.D. · Principal investigator
    Recruiting
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 6, 2008, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00629668
Lead sponsor
Kaohsiung Medical University Chung-Ho Memorial Hospital
First posted
Mar 6, 2008
Start date
Jan 2007
Completion
Dec 2007 (estimated)
Last update
Mar 6, 2008

Study contacts

Jen-Eing Jeng, M.D.
principal investigator · Assistant Professor of Clinical Laboratory

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Jul 2007. You cannot join it, but the record below documents what was studied.

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