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Status unknownNCT00628082Updated Mar 4, 2008

Energetic Abnormalities in Heart Failure With Preserved Ejection Fraction

An observational study in Heart Failure, Diastolic, sponsored by University Hospital Birmingham. Status unknown at 1 site in United Kingdom. Open to participants aged 40 Years to 85 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2008-03-04.

Sponsored by University Hospital Birmingham · Observational

The sponsor has not verified this record recently (last verified Feb 2008), so the status shown — last known as Recruiting — may be out of date.
Study type
Observational
Model
Cohort
Enrollment
50
Ages
40 Years to 85 Years
Sex
All
01

Study summary

Up to half of all patients with heart failure are found to have normal pumping function of the heart muscle, but show abnormalities in the way the heart muscle relaxes and fills with blood. These patients often have high blood pressure, and tend to have stiff arteries and stiff heart muscle. We wish to test the hypothesis that these patients have abnormal energy stores in their heart muscle.

02

Conditions studied

  • Heart Failure, Diastolic

Keywords

  • Cardiac Energetics
  • Dynamic Diastolic filling Assessment
  • Heart Failure with Preserved Ejection Fraction
  • Arterial and Ventricular Stiffening
03

In context

Heart Failure

5,701 studies on the registry are indexed under Heart Failure; 1,220 are open to participants now.

This study's planned enrollment of 50 is below the median of 200 across 1,679 observational studies indexed under Heart Failure.

Browse Heart Failure studies →

Lead sponsor

University Hospital Birmingham is the lead sponsor of 32 studies on the registry; 2 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
40 Years to 85 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Heart Failure Clinic

Inclusion criteria

  • Clinical features consistent with heart failure
  • LVEF ≥ 50%, with no evidence of significant valvular disease, no hypertrophic cardiomyopathy, and no evidence of pericardial constriction
  • A peak VO2 \< 80% predicted, with a pattern of gas exchange on metabolic exercise testing indicating a cardiac cause for limitation

Exclusion criteria

Exclusion Criteria:

  • Objective evidence of lung disease on formal lung function testing
  • Reversible myocardial ischaemia on contrast-enhanced myocardial stress
  • Echocardiography, and evidence of exercise-induced mitral regurgitation
  • Obesity (BMI >35) or a locomotor cause for exercise limitation
05

Study design

Observational model
Cohort
Enrollment
50 participants (estimated)

Groups and cohorts

  • HfpEF

    Patients with Heart Failure with preserved ejection fraction

  • Control

    Healthy Volunteers

06

What researchers measure

Primary outcomes

  1. Complete echocardiographic assessment to assess resting diastolic function

    Time frame: 1 DAY

  2. Assessment of resting large artery function

    Time frame: 1 DAY

  3. Multiple Gated Acquisition Scan

    Time frame: 1 DAY

  4. Cardiac Magnetic Resonance Spectroscopy

    Time frame: 1 DAY

  5. Metabolic Exercise Testing (VO2max)

    Time frame: 1 DAY

07

Study locations

1 of 1 sites recruiting
  • University of Birmingham
    Birmingham, B15 2TT, United Kingdom
    • Thanh T Phan, MRCP · Contact · ttpquang@hotmail.com · 01214145916
    • Thanh T Phan, MRCP · Sub investigator
    Recruiting
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 4, 2008, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00628082
Lead sponsor
University Hospital Birmingham
Collaborators
Heart of England NHS Trust, British Heart Foundation
First posted
Mar 4, 2008
Start date
Mar 2006
Primary completion
Apr 2009 (estimated)
Completion
Apr 2009 (estimated)
Last update
Mar 4, 2008

Study contacts

Thanh T Phan, MRCP
Contact
ttpquang@hotmail.com
01214145916
Michael Frenneaux, FRCP
principal investigator · University of Birmingham

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Feb 2008. You cannot join it, but the record below documents what was studied.

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