An observational study in Aortic Valve Stenosis and Aortic Valve Insufficiency, sponsored by The Cleveland Clinic. Withdrawn at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2017-01-11.
Sponsored by The Cleveland Clinic · Observational
The purpose of this study is to perform ground-based research to study what happens to the heart muscle in space. People who have problems with their aortic valve have an increase in the amount of muscle in the left ventricle of the heart. After valve surgery, the amount of muscle should decrease and return to normal. Astronauts lose heart muscle mass during space flight. Our study will look at these changes in your heart, which we believe are similar to what happens during long term space travel.
This study will look at the accuracy of three dimensional ultrasound imaging (echo) in monitoring the changes in heart size and function following aortic valve replacement. We are studying ways to prevent health-related problems that men and women will face on long-duration space missions.
The hypothesis is that serial two dimensional and three dimensional echo will show accurate changes in the left ventricle mass and volume following aortic valve replacement for aortic stenosis or regurgitation
Diagnostic Three Dimensional Echocardiography Study Protocol
A. Aims The overall purpose of this study is to perform ground-based research, development, and validation aimed at optimizing diagnostic ultrasound in manned spaceflight, with the following unifying hypothesis: Serial 3D ultrasound examinations will enhance diagnostic capabilities in manned spaceflight.
Specific Aims:
Hypotheses:
985 studies on the registry are indexed under Aortic Valve Stenosis; 283 are open to participants now.
Browse Aortic Valve Stenosis studies →The Cleveland Clinic is the lead sponsor of 818 studies on the registry; 118 are open to participants now.
Of its 89 completed or terminated interventional studies of FDA-regulated products, 72 (81%) have results posted.
Counted across the registry records on this site, refreshed daily.
Patients coming to Cleveland Clinic to have surgery for aortic stenosis or aortic insufficiency.
Exclusion Criteria:
Diagnostic 2D and 3D echocardiography
Time frame: 6 - 12 months
BNP levels
Time frame: 6-12 months
MRI
Time frame: 6-12 months
Plan to share: No
No publications or documents are linked to this record.
This study is withdrawn, as verified in Jan 2008. You cannot join it, but the record below documents what was studied.
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