ClinicalTrials.gg
Status unknownNCT00563888Updated Nov 26, 2007

Change of Neural Network Indicators Through Narrative Treatment of PTSD in Torture Victims

An interventional study of NET in PTSD, sponsored by University of Konstanz. Status unknown at 1 site in Germany. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2007-11-26.

Sponsored by University of Konstanz · Not applicable, Interventional, and Treatment

The sponsor has not verified this record recently (last verified Nov 2007), so the status shown — last known as Active, not recruiting — may be out of date.
Phase
Not applicable
Study type
Interventional
Enrollment
30
Allocation
Randomized
Ages
18 Years to 65 Years
Sex
All
01

Study summary

Effective Treatment of PTSD involves talking about the traumatic event in detail.It is unclear how this process influences the sensory-specific trauma network (fear structure)in the traumatized person. The goal of the project is to test the hypothesis that treatment-facilitated recovery does not change the original fear structure but establishes an inhibitory mechanism that depends on verbal activity. An affective visual steady-state paradigm in magnetencephalography (MEG) using positive, aversive and neutral picture stimuli will be used to examine the spatial and temporal pattern of the processing of emotional stimuli. To examine the effects of treatment this paradigm will be used as outcome measure within a randomized controlled trial of Narrative Exposure Therapy and a waiting-list control condition for severely traumatized torture victims.

02

Conditions studied

  • PTSD

Keywords

  • PTSD
  • torture survivors
  • Narrative Exposure Therapy
  • trauma-related memory processes
  • steady state visual evoked fields
03

In context

Stress Disorders, Post-Traumatic

2,284 studies on the registry are indexed under Stress Disorders, Post-Traumatic; 557 are open to participants now.

This study's planned enrollment of 30 is below the median of 70 across 1,897 interventional studies indexed under Stress Disorders, Post-Traumatic.

Browse Stress Disorders, Post-Traumatic studies →

Lead sponsor

University of Konstanz is the lead sponsor of 51 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • experiences of organized violence/torture
  • PTSD diagnosis

Exclusion criteria

Exclusion Criteria:

  • psychotic disorder
  • neurological disease or seizures
  • current drug/alcohol abuse
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single (Outcomes assessor)
Enrollment
30 participants (estimated)

Study arms

  • Experimental
    A

    Narrative Exposure Therapy (NET)

    Behavioral: NET

  • No intervention
    B

    Waitinglist Control Group

Interventions

  • BehavioralNET

    Narrative Exposure Therapy for traumatized survivors of organized violence

06

What researchers measure

Primary outcomes

  1. PTSD diagnosis and severity score according to the Clinicians Administered PTSD Scale (CAPS)

    Time frame: 4 & 9 months after completion of treatment

Secondary outcomes

  1. steady state visual evoked magnetic fields in response to affective stimuli

    Time frame: 4 & 9 months after completion of treatment

07

Study locations

1 site
  • University of Konstanz, Department of Psychology
    Konstanz, 78467, Germany
08

References and documents

Publications

  • Adenauer H, Catani C, Gola H, Keil J, Ruf M, Schauer M, Neuner F. Narrative exposure therapy for PTSD increases top-down processing of aversive stimuli--evidence from a randomized controlled treatment trial. BMC Neurosci. 2011 Dec 19;12:127. doi: 10.1186/1471-2202-12-127. PubMed 22182346 ↗
  • Adenauer H, Pinosch S, Catani C, Gola H, Keil J, Kissler J, Neuner F. Early processing of threat cues in posttraumatic stress disorder-evidence for a cortical vigilance-avoidance reaction. Biol Psychiatry. 2010 Sep 1;68(5):451-8. doi: 10.1016/j.biopsych.2010.05.015. PubMed 20619396 ↗
09

Timeline

Tracking since Sep 25, 2026
Not marked actual or estimatedDates not marked actual or estimated

The record gives a start of Jan 2007 and a completion of Dec 2008. It does not say whether these dates are actual or estimated.

How these figures are worked out, and which studies are left out of them.

Registered
Nov 23, 2007
First posted
Nov 26, 2007
Start
Jan 2007
CompletionEst.
Dec 2008
Last update
Nov 26, 2007
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Nov 26, 2007, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT00563888
Lead sponsor
University of Konstanz
Collaborators
German Research Foundation
First posted
Nov 26, 2007
Start date
Jan 2007
Completion
Dec 2008 (estimated)
Last update
Nov 26, 2007

Study contacts

Claudia Catani, Dr.
study director · University of Konstanz
Frank Neuner, Prof.
principal investigator · University of Konstanz

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Nov 2007. You cannot join it, but the record below documents what was studied.

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