ClinicalTrials.gg
CompletedNCT00551837Updated Oct 24, 2017

Immune Response to Influenza Vaccination

An observational study in Solid Organ Transplantation and Chronic Kidney Disease, sponsored by The Cleveland Clinic. Completed. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2017-10-24.

Sponsored by The Cleveland Clinic · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
82
Ages
18 Years and older
Sex
All
01

Study summary

The purpose of this study is to evaluate the immune response to a routine influenza vaccination. Influenza vaccination is given as part of routine standard of care in these individuals and is not part of the study protocol. The study will evaluate for a change in response to common antigens over time after influenza vaccination to determine if changes are related to the development of chronic rejection after solid-organ transplantation. We hypothesize that the influenza vaccine contributes to the alloreactivity of T cells verses common HLA types in the donor pool.

02

Conditions studied

  • Solid Organ Transplantation
  • Chronic Kidney Disease

Keywords

  • Lung Transplantation
  • Kidney Transplnatation
  • Chroinic Kidney Disease
  • Influenza
03

In context

Renal Insufficiency, Chronic

3,224 studies on the registry are indexed under Renal Insufficiency, Chronic; 706 are open to participants now.

This study's enrollment of 82 is below the median of 200 across 889 observational studies indexed under Renal Insufficiency, Chronic.

Browse Renal Insufficiency, Chronic studies →

Lead sponsor

The Cleveland Clinic is the lead sponsor of 831 studies on the registry; 119 are open to participants now.

Of its 90 completed or terminated interventional studies of FDA-regulated products, 73 (81%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Lung and kidney transplant recipients, patients with chronic kidney disease and healthy controls

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Transplant recipients (lung or kidney) 18 years or older, more than 3 months after transplantation
  • Transplant candidates (kidney) 18 years or older, to recieve influenza vaccination
  • Healthy volunteers to receive influenza vaccination

Exclusion criteria

Exclusion Criteria:

  • Under 18 years of age
  • Pregnant
  • Medical contraindication for vaccine
  • Transplant recipients receiving acute rejection therapy within one month
  • Healthy volunteers with autoimmune disease or medications to mediate immune function
  • Receipt of live, attenuated influenza vaccine, instead of injectable vaccine
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
82 participants (actual)
06

Study locations

No study locations are listed for this record.

07

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 24, 2017, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
08

Registry details

Key details

Study ID
NCT00551837
Responsible party
Sponsor
First posted
Oct 31, 2007
Start date
Nov 2006
Primary completion
Apr 2008
Completion
May 2008
Last update
Oct 24, 2017

Study contacts

Emilio Poggio, MD
study director · The Cleveland Clinic
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Oct 2017. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion