CClinicalTrials.gg
CompletedNCT00535964Updated Nov 17, 2022

Evaluating the Relationship Between Tobacco Use, Anxiety Sensitivity, and Panic in Adolescents

An observational study in Panic Disorder, sponsored by University of Arkansas, Fayetteville. Completed at 1 site in United States. Open to participants aged 12 Years to 17 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-11-17.

Sponsored by University of Arkansas, Fayetteville · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
180
Ages
12 Years to 17 Years
Sex
All
01

Study summary

This study will determine whether there is a relationship between tobacco use and a heightened response to panic-producing events among adolescents. This study is fundamental research. It was not a Clinical Trial.

Read the detailed description

Growing up is hard enough, and adolescence can be a particularly stressful time in people's lives as they adjust to the transition from childhood to adulthood. Peer pressure can add to this anxiety, making it more likely for teens to take part in risky behaviors such as smoking cigarettes. Every day, more than 4,000 teens smoke their first cigarette and nearly half of those teens will become regular, daily smokers. Cigarette smoking is associated with a multitude of health risks, including an increased likelihood of experiencing panic attacks, anxiety disorders, and depression. This study will evaluate a group of teens, ranging from those who have never smoked to those who smoke daily, to determine whether there is a relation between adolescent smoking history and their vulnerability to panic-producing situations.

Participants in this study will undergo a brief medical screening, followed by a short interview that will include several questionnaires regarding emotions, experiences, and personal habits. Participants will then attend a series of laboratory assessments for 1 hour. The first assessment will include a 3-minute voluntary hyperventilation procedure in which participants will be directed when to breathe in and when to breathe out, at a faster rate than normal. Participants will then take part in two computerized tasks: one will be a computerized task that involves blowing up a balloon and deciding when to quit before the balloon pops; the other task will involve choosing hypothetical amounts of money now or after a period of delay. During the laboratory assessments, all participants will have electrodes attached to their bodies and sensors around their chests to measure heart rate, palm sweating, and muscle tension. Results from this study will be used to evaluate the association between smoking and increased panic levels under stressful conditions among adolescents.

02

Conditions studied

  • Panic Disorder

Keywords

  • Cigarette Smoking
  • Tobacco Use
  • Adolescents
  • Anxiety Sensitivity (AS)
03

In context

Hypersensitivity

1,916 studies on the registry are indexed under Hypersensitivity; 265 are open to participants now.

This study's enrollment of 180 is above the median of 115 across 479 observational studies indexed under Hypersensitivity.

Browse Hypersensitivity studies →

Lead sponsor

University of Arkansas, Fayetteville is the lead sponsor of 29 studies on the registry; 8 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
12 Years to 17 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Study population

Participants will be 180 psychologically healthy adolescents, evenly divided across the various stages of smoking uptake (i.e., non-smokers, tried smoking, experimenters, regular smokers, and daily smokers).

Inclusion criteria

  • Adolescents, ranging from those who have never smoked to those who smoke daily

Exclusion criteria

Exclusion Criteria:

  • Current or past diagnosis of a panic disorder
  • Acute or chronic cardiopulmonary or respiratory illness (e.g., asthma or bronchitis)
  • Pregnant
05

Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
180 participants (actual)
Patient registry
No

Groups and cohorts

  • 1

    Psychologically healthy adolescents, evenly divided across the various stages of smoking uptake

06

What researchers measure

Primary outcomes

  1. Relationship between cigarette smoking and panic vulnerability

    Time frame: Measured at completion of laboratory testing analysis

07

Study locations

1 site
  • University of Arkansas
    Fayetteville, Arkansas 72701, United States
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Nov 17, 2022, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00535964
Lead sponsor
University of Arkansas, Fayetteville
Collaborators
National Institute of Mental Health (NIMH)
Responsible party
Ellen Leen-Feldner (Professor of Psychology, University of Arkansas, Fayetteville) — Principal investigator
First posted
Sep 27, 2007
Start date
Jun 2007
Primary completion
Apr 2009
Completion
Apr 2009
Last update
Nov 17, 2022

Study contacts

Ellen W. Leen-Feldner, PhD
principal investigator · University of Arkansas

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Nov 2022. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion