An interventional study of varenicline in Smoking and Depressive Disorder, sponsored by Butler Hospital. Withdrawn at 1 site in United States. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2015-07-21.
Sponsored by Butler Hospital · Not applicable, Interventional, and Treatment
This study of psychiatric inpatients will assess mood effects of varenicline, as well as assess if varenicline decreased nicotine cravings acutely.
This study will also measure side effects of varenicline when given in addition to other psychiatric and non-psychiatric medications.
This study will measure mood effects and rapid anti-craving effects of varenicline in psychiatric inpatients. Patients will be offered to participate in the trial if they wish to stop smoking or wish to decrease nicotine cravings while in the hospital. They will not be able to use nicotine replacement products when taking varenicline.
Patients will be assessed with the QIDS-SR16, Minnesota Nicotine Withdrawal Scale as well as the Frequency, Intensity, and Burden of Side Effects (FISER) at baseline and daily during the trial; patients will be asked to enroll for the duration of their hospitalization. Patients will be assessed as to whether they wish to continue varenicline post-discharge.
4,845 studies on the registry are indexed under Depressive Disorder; 514 are open to participants now.
Browse Depressive Disorder studies →Butler Hospital is the lead sponsor of 113 studies on the registry; 11 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
(3) Current pregnancy or breastfeeding.
varenicline 0.5mg daily for days 1-3, 0.5mg twice daily for days 3-7, then 1mg twice daily for length of hospitalization
Also known as: Chantix
improvement in Quick Inventory of Depressive Symptoms (QIDS-SR)
Time frame: duration of hospitalization
improvement in Minnesota Nicotine Withdrawal Scale
Time frame: days (duration of hospitalization)
no significant intolerability, measured by the Frequency, Intensity, and Burden of Side Effects (FIBSER) and Adverse Events Checklist (SAFTEE-SI)
Time frame: duration of hospitalization
This study is withdrawn, as verified in Jul 2015. You cannot join it, but the record below documents what was studied.
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Butler Hospital