CClinicalTrials.gg
WithdrawnNCT00518921Updated Jan 13, 2011

Capadenoson in Angina Pectoris

A Phase 2 interventional study of Capadenoson (BAY 68-4986) and Capadenoson (BAY 68-4986) in Chronic Stable Angina, sponsored by Bayer. Withdrawn at 36 sites in 6 countries. Open to participants aged 35 Years to 75 Years. Per ClinicalTrials.gov, last updated 2011-01-13.

Sponsored by Bayer · Phase 2, Interventional, and Treatment

Phase
Phase 2
Study type
Interventional
Enrollment
0
Allocation
Randomized
Ages
35 Years to 75 Years
Sex
All
01

Study summary

This is a multi-center and multi-national,randomized, double blind, placebo-controlled, 28-day treatment study with BAY 68-4986 taken orally or a matching placebo.

02

Conditions studied

  • Chronic Stable Angina

Keywords

  • adenosin agonist
  • chronic stable angina
03

In context

Angina Pectoris

519 studies on the registry are indexed under Angina Pectoris; 82 are open to participants now.

Browse Angina Pectoris studies →

Lead sponsor

Bayer is the lead sponsor of 1,643 studies on the registry; 57 are open to participants now.

Of its 209 completed or terminated interventional studies of FDA-regulated products, 129 (62%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
35 Years to 75 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • The primary diagnosis is chronic stable angina of mild-moderate intensity as defined by the Canadian Cardiovascular Society Functional Class II-III, in the presence of definitive coronary artery disease.
  • Male or female subjects aged 35 to 75 years (if female, only if postmenopausal or permanently sterilized)
  • Stable angina of mild-moderate intensity (Canadian class II-III) with anti-anginal medication not changed for the last 5 weeks

Exclusion criteria

Exclusion Criteria:

  • Inability to withdraw current anti-anginal therapy
  • Inability to withdraw any concomitant therapy that would interfere with interpretation of study results
05

Study design

Phase
Phase 2
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Triple (Participant, Care provider, Investigator)
Enrollment
0 participants (actual)

Study arms

  • Experimental
    Arm 1

    Drug: Capadenoson (BAY 68-4986)

  • Experimental
    Arm 2

    Drug: Capadenoson (BAY 68-4986)

  • Experimental
    Arm 3

    Drug: Capadenoson (BAY 68-4986)

  • Placebo comparator
    Arm 4

    Drug: Placebo

Interventions

  • DrugCapadenoson (BAY 68-4986)

    1mg Capadenoson, double dummy

  • DrugCapadenoson (BAY 68-4986)

    2mg Capadenoson, double dummy

  • DrugCapadenoson (BAY 68-4986)

    4mg Capadenoson, double dummy

  • DrugPlacebo

    Placebo, double dummy

06

What researchers measure

Primary outcomes

  1. Total exercise time

    Time frame: 28 days for ETT and 42 days for safety

Secondary outcomes

  1. Time to angina onset

    Time frame: 28 days

07

Study locations

36 sites
  • Brno, 656 91, Czech Republic
  • Hodonin, 695 26, Czech Republic
  • Kromeriz, 767 55, Czech Republic
  • Olomouc, 775 20, Czech Republic
  • Ostrava, 708 52, Czech Republic
  • Plzen, 30599, Czech Republic
  • Praha 13, 158 00, Czech Republic
  • Praha 6, 169 02, Czech Republic
  • Balatonfured, 8230, Hungary
  • Kecskemet, 6000, Hungary
  • Miskolc, 3526, Hungary
  • Pecs, 7624, Hungary
  • Zalaegerszeg, 8900, Hungary
  • Hadera, 38100, Israel
  • Rehovot, 76100, Israel
  • Safed, 13100, Israel
  • Mestre, Venezia 30174, Italy
  • Genova, 16132, Italy
  • Pavia, 27100, Italy
  • Trieste, 34100, Italy
  • Bialystok, 15-276, Poland
  • Gdansk, 80-952, Poland
  • Gdynia, 81-519, Poland
  • Katowice, 40-635, Poland
  • Krakow, 30-501, Poland
  • Legnica, 59-220, Poland
  • Lodz, 91-347, Poland
  • Starogard Gdanski, 83-200, Poland
  • Szczecin, 70-111, Poland
  • Warszawa, 03-401, Poland
  • Wroclaw, 50-420, Poland
  • Wroclaw, 50-981, Poland
  • Bratislava, 811 04, Slovakia
  • Bratislava, 813 69, Slovakia
  • Nitra, 949 01, Slovakia
  • Nove Zamky, 940 34, Slovakia
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 13, 2011, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00518921
Lead sponsor
Bayer
First posted
Aug 21, 2007
Start date
Mar 2008
Completion
Nov 2008 (estimated)
Last update
Jan 13, 2011

Study contacts

Bayer Study Director
study director · Bayer

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is withdrawn, as verified in Jan 2011. You cannot join it, but the record below documents what was studied.

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