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CompletedNCT00501579Updated Aug 29, 2008

Study of Difluprednate in the Treatment of Uveitis

A Phase 3 interventional study of Difluprednate and Prednisolone Acetate in Uveitis, sponsored by Sirion Therapeutics, Inc.. Completed at 1 site in United States. Open to participants aged 2 Years and older. Per ClinicalTrials.gov, last updated 2008-08-29.

Sponsored by Sirion Therapeutics, Inc. · Phase 3 and Interventional

Phase
Phase 3
Study type
Interventional
Allocation
Randomized
Ages
2 Years and older
Sex
All
01

Study summary

The purpose of this study is to determine the safety and efficacy of difluprednate compared with prednisolone acetate in the treatment of endogenous anterior uveitis.

02

Conditions studied

  • Uveitis

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03

In context

Uveitis

335 studies on the registry are indexed under Uveitis; 37 are open to participants now.

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Lead sponsor

Sirion Therapeutics, Inc. is the lead sponsor of 15 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
2 Years and older
Sexes eligible
All

Inclusion criteria

  • Diagnosis of endogenous anterior uveitis in at least 1 eye

Exclusion criteria

Exclusion Criteria:

  • Presence of intermediate uveitis, posterior uveitis or panuveitis
  • Corneal abrasion
  • Any confirmed or suspected active viral, bacterial, or fungal keratoconjunctival disease
  • Allergy to similar drugs, such as other corticosteroids
05

Study design

Phase
Phase 3
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double

Interventions

  • DrugDifluprednate
  • DrugPrednisolone Acetate
06

Study locations

1 site
  • John-Kenyon American Eye Institute
    New Albany, Indiana 47150, United States
07

References and documents

Publications

  • Foster CS, Davanzo R, Flynn TE, McLeod K, Vogel R, Crockett RS. Durezol (Difluprednate Ophthalmic Emulsion 0.05%) compared with Pred Forte 1% ophthalmic suspension in the treatment of endogenous anterior uveitis. J Ocul Pharmacol Ther. 2010 Oct;26(5):475-83. doi: 10.1089/jop.2010.0059. PubMed 20809807 ↗
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 29, 2008, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00501579
Lead sponsor
Sirion Therapeutics, Inc.
First posted
Jul 16, 2007
Last update
Aug 29, 2008

Study contacts

Roger Vogel, MD
study chair · Sirion Therapeutics
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Aug 2008. You cannot join it, but the record below documents what was studied.

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