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CompletedNCT00465777MTVUpdated Apr 25, 2007

Improved Management and in-Hospital Mortality

An interventional study of Guideline adherence and financial incentive in Mortality and Malaria, sponsored by Bandim Health Project. Completed at 1 site in Guinea-Bissau. Open to participants aged 3 Months to 5 Years. Per ClinicalTrials.gov, last updated 2007-04-25.

Sponsored by Bandim Health Project · Not applicable, Interventional, and Health services research

Phase
Not applicable
Study type
Interventional
Enrollment
950
Allocation
Randomized
Ages
3 Months to 5 Years
Sex
All
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Study summary

The study intend to evaluate whether the use of standardised malaria case management protocol plus financial incentives added to the availability of free drugs reduce the case-fatality at the paediatric ward.

Read the detailed description

Mortality at the national paediatric ward in Guinea-Bissau is very high. During a civil war in 1998/1999 the hospital case fatality (CF) decreased by more than 40%, increasing again after the the war. This was attributed to the available free drugs from the humanitarian aid and food incentives to the personnel. Free emergency kits for treatment of severe malaria was introduced, however the CF did not decline. Therefore, the ward was split into two groups of rooms: intervention and control. All the staff of the ward was trained in the use of a standardised guideline for treatment of severe malaria and randomly assigned to one of the groups. All children hospitalised for malaria received the drug emergency kits. The only difference in the intervention group were the small financial incentives and supervision for strict adherence to the guidelines procedures.

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Conditions studied

  • Mortality
  • Malaria

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Keywords

  • malaria
  • mortality
  • hospital
  • incentive
  • personnel
  • paediatric
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In context

Malaria

1,299 studies on the registry are indexed under Malaria; 86 are open to participants now.

This study's enrollment of 950 is above the median of 220 across 1,027 interventional studies indexed under Malaria.

Browse Malaria studies →

Lead sponsor

Bandim Health Project is the lead sponsor of 59 studies on the registry; 5 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
3 Months to 5 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Hospitalization due to malaria
  • Non per os

Exclusion criteria

Exclusion Criteria:

  • Consent from parent/caretaker declined
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Study design

Phase
Not applicable
Primary purpose
Health services research
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
950 participants

Interventions

  • BehavioralGuideline adherence and financial incentive
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What researchers measure

Primary outcomes

  1. In-hospital case-fatality

Secondary outcomes

  1. Cumulative post-discharge mortality on day 28 and length of hospitalisation

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Study locations

1 site
  • Bandim Health Project
    Bissau, 1004, Guinea-Bissau
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References and documents

Publications

  • Biai S, Rodrigues A, Gomes M, Ribeiro I, Sodemann M, Alves F, Aaby P. Reduced in-hospital mortality after improved management of children under 5 years admitted to hospital with malaria: randomised trial. BMJ. 2007 Oct 27;335(7625):862. doi: 10.1136/bmj.39345.467813.80. Epub 2007 Oct 22. PubMed 17954513 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Apr 25, 2007, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00465777
Lead sponsor
Bandim Health Project
Collaborators
Statens Serum Institut, World Health Organization
First posted
Apr 25, 2007
Start date
Dec 2004
Completion
Feb 2006
Last update
Apr 25, 2007

Study contacts

Peter Aaby, DMSc
study chair · Bandim Health Project

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Apr 2007. You cannot join it, but the record below documents what was studied.

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