An interventional study of Vitamin D and calcitriol in Hypertension, sponsored by Atlanta VA Medical Center. Withdrawn at 1 site in United States. Open to participants aged 18 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2014-01-08.
Sponsored by Atlanta VA Medical Center · Not applicable, Interventional, and Treatment
Vitamin D is a natural nutrient in normal daily diet. It can also be made in the skin after exposure to sunlight and is essential for maintaining normal calcium balance. One past study has suggested that vitamin D may be helpful for blood pressure. This study will test whether pills containing cholecalciferol (a form of vitamin D) or calcitriol (the active form of vitamin D) can treat high blood pressure. The investigators plan to enroll up to 80 subjects at the Atlanta VA Medical Center. Participation in the study is expected to last up to 4 weeks. Subjects will be assigned to cholecalciferol, calcitriol or placebo). A 24-hour blood pressure monitor will be worn at the beginning and end of the study to determine blood pressure changes. Renin, PTH, angiotensin-II, and aldosterone levels will also be measured at the beginning and end of the study.
6,689 studies on the registry are indexed under Hypertension; 965 are open to participants now.
Browse Hypertension studies →Atlanta VA Medical Center is the lead sponsor of 15 studies on the registry; 1 is open to participants now.
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Exclusion Criteria:
Drug: Placebo
Cholecalciferol
Drug: Vitamin D
Calcitriol
Drug: calcitriol
200,000 IU once weekly for 3 weeks (600,000 IU total dose)
calcitriol 0.5 mcg twice a day for 1 week
Placebo once a week for 3 weeks
Blood pressure
Time frame: 3 Weeks
25(OH)D
Time frame: 3 weeks
Parathyroid hormone
Time frame: 3 weeks
Renin
Time frame: 3 weeks
Aldosterone
Time frame: 3 weeks
Angiotensin II
Time frame: 3 weeks
This study is withdrawn, as verified in Jan 2014. You cannot join it, but the record below documents what was studied.
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Atlanta VA Medical Center