A Phase 3 interventional study of Intravitreal Injection of Bevacizumab (1.25 mg/0.05ml) in Retina and Telangiectasis, sponsored by University of Sao Paulo. Completed at 1 site in Brazil. Open to participants aged 40 Years and older. Per ClinicalTrials.gov, last updated 2008-07-23.
Sponsored by University of Sao Paulo · Phase 3, Interventional, and Treatment
Idiopathic Macular Telangiectasia is characterized by incompetent and dilated retinal capillaries in the foveolar region of unknown cause for retinal telangiectasia.
In Idiopathic Macular Telangiectasia, proliferative changes occur in the deep retinal capillary network, leading to intraretinal neovascularization that, unlike in age-related macular degeneration, seems to be retinal rather than choroidal in origin. Before the hemorrhagic and fibrotic state, these vessels may lead to exudation and decrease in the visual acuity. Long-term visual prognosis in patients with this complication may be poor and treatment with laser photocoagulation is unproven. Although newly reported treatment, by photodynamic therapy for neovascular membrane associated with Idiopathic Macular Telangiectasia, may show vision and angiographic stability in a few cases, the improvement may be transient. VEGF has been implicated as the major angiogenic stimulus responsible for neovascularization in AMD, ensuing specific anti-VEGF treatment in these cases.
The purpose of the study is to evaluate intravitreal injection of bevacizumab (1.25mg/0.05ml) in the treatment of Idiopathic Macular Telangiectasia.
153 studies on the registry are indexed under Telangiectasis; 16 are open to participants now.
This study's enrollment of 31 is close to the median of 30 across 107 interventional studies indexed under Telangiectasis.
Browse Telangiectasis studies →University of Sao Paulo is the lead sponsor of 1,005 studies on the registry; 90 are open to participants now.
Of its 7 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
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Exclusion Criteria:
Visual acuity
Optical coherence tomography
Fluorescein angiography
This study is completed, as verified in Mar 2007. You cannot join it, but the record below documents what was studied.
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University of Sao Paulo