A Phase 1 interventional study of dexamethasone in Cancer, sponsored by Sunnybrook Health Sciences Centre. Completed at 1 site in Canada. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2014-11-19.
Sponsored by Sunnybrook Health Sciences Centre · Phase 1, Interventional, and Treatment
Radiation treatment is often recommended as a safe and quick treatment that gives most people good relief from bone pain within a couple of weeks. However, some people can experience a short episode of increased pain (called a 'flare') a day or two after radiation treatment, that lasts about a day. The purpose of this sturdy is to find out if a medication called dexamethasone can help prevent pain flare as a result of radiation therapy.
Of all people diagnosed with cancer, 25% will have their cancer come back and spread to the bones. This often results in significant pain and suffering. Radiation treatment is often recommended as a safe and quick treatment that gives most people good relief from bone pain within a couple of weeks. However, some people can experience a short episode of increased pain called a flare a day or two after radiation treatment that lasts about a day. Studies suggest that around a third of all people who receive radiation treatment to help pain from cancer in the bones will have a pain flare. This study is being done because it would be helpful to prevent extra bone pain from happening to people after they receive radiation treatments. The purpose of this study is to find out if a medication called dexamethasone can help prevent pain flare as a result of radiation therapy.
9,610 studies on the registry are indexed under Neoplasms; 2,508 are open to participants now.
This study's enrollment of 61 is above the median of 50 across 7,429 interventional studies indexed under Neoplasms.
Browse Neoplasms studies →Sunnybrook Health Sciences Centre is the lead sponsor of 582 studies on the registry; 133 are open to participants now.
Of its 6 completed or terminated interventional studies of FDA-regulated products, 2 (33%) have results posted.
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Exclusion Criteria:
8mg Dexamethasone PO on days 0 (prior to radiation treatment), and days 1, 2, and 3 following radiation treatment.
Drug: dexamethasone
8mg Dexamethasone PO on days 0 (prior to radiation treatment), and days 1, 2, and 3 following radiation treatment.
Also known as: Decadron
Complete control of pain flare on days 1-5 after the completion of radiation treatment.
Time frame: Days 1-5
Complete control of pain flare from Day 6-10 after the completion of radiation treatment.
Time frame: Days 6-10
Functional interference especially mood and sleep in Brief Pain Inventory will be monitored.
Time frame: Days 0, 1-10, and 6-weeks from baseline assessment
Quality of life outcomes
Time frame: Baseline and 6-weeks following treatment
This study is completed, as verified in Nov 2014. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Dexamethasone
Sunnybrook Health Sciences Centre →