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CompletedNCT00436111Updated Feb 16, 2007

Characterization of Macroprolactinemia

An observational study in Hyperprolactinemia, sponsored by Kansai Medical University. Completed at 1 site in Japan. Per ClinicalTrials.gov, last updated 2007-02-16.

Sponsored by Kansai Medical University · Observational

Study type
Observational
Model
Defined population
Time perspective
Retrospective
Sex
All
01

Study summary

The purpose of this study is to clarify the nature of macroprolactin which has recently been highlighted because of the high prevalence and a diagnostic pitfall of hyperprolactinemia. The results of this study are beneficial for the patients to whom unnecessary medications and unnecessary radiological examinations have been performed.

We used the remained serum samples taken for routine prolactin determination during the past several years. Since the blood was basically taken to examine the causes of hyperprolactinemia and only remained serum samples were used for this study, the Ethics Committee of Kobe City General Hospital judged that it was not required to obtain approval number.

02

Conditions studied

  • Hyperprolactinemia

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Keywords

  • hyperprolactinemia
  • autoantibody
03

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All

Eligibility criteria

Inclusion Criteria:

  • Clinical diagnosis of hyperprolactinemia
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Study design

Observational model
Defined population
Time perspective
Retrospective
05

Study locations

1 site
  • Kansai Medical University
    Osaka, 570-8506, Japan
06

References and documents

Publications

  • Hattori N, Nakayama Y, Kitagawa K, Ishihara T, Saiki Y, Inagaki C. Anti-prolactin (PRL) autoantibody-binding sites (epitopes) on PRL molecule in macroprolactinemia. J Endocrinol. 2006 Aug;190(2):287-93. doi: 10.1677/joe.1.06871. PubMed 16899562 ↗
  • Hattori N, Ikekubo K, Nakaya Y, Kitagawa K, Inagaki C. Immunoglobulin G subclasses and prolactin (PRL) isoforms in macroprolactinemia due to anti-PRL autoantibodies. J Clin Endocrinol Metab. 2005 May;90(5):3036-44. doi: 10.1210/jc.2004-1600. Epub 2005 Feb 1. PubMed 15687336 ↗
  • Hattori N, Inagaki C. Anti-prolactin (PRL) autoantibodies cause asymptomatic hyperprolactinemia: bioassay and clearance studies of PRL-immunoglobulin G complex. J Clin Endocrinol Metab. 1997 Sep;82(9):3107-10. doi: 10.1210/jcem.82.9.4250. PubMed 9284753 ↗
  • Hattori N, Ishihara T, Ikekubo K, Moridera K, Hino M, Kurahachi H. Autoantibody to human prolactin in patients with idiopathic hyperprolactinemia. J Clin Endocrinol Metab. 1992 Nov;75(5):1226-9. doi: 10.1210/jcem.75.5.1430082. PubMed 1430082 ↗
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Registry details

Key details

Study ID
NCT00436111
Lead sponsor
Kansai Medical University
First posted
Feb 16, 2007
Start date
Jan 2005
Completion
Dec 2006
Last update
Feb 16, 2007

Study contacts

Naoki Hattori, M.D., Ph.D.
study chair · Department of Pharmacology, Kansai Medical University
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Feb 2007. You cannot join it, but the record below documents what was studied.

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