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CompletedNCT00432393Updated Oct 20, 2008

Effect of Levodopa-Carbidopa on Visual Function in Patients With Recent-Onset Nonarteritic Anterior Ischemic Optic Neuropathy

A Phase 4 interventional study of levodopa-carbidopa in Nonarteritic Anterior Ischemic Optic Neuropathy, sponsored by Shahid Beheshti University of Medical Sciences. Completed at 1 site in Iran, Islamic Republic of. Open to participants aged 50 Years and older. Per ClinicalTrials.gov, last updated 2008-10-20.

Sponsored by Shahid Beheshti University of Medical Sciences · Phase 4, Interventional, and Treatment

Phase
Phase 4
Study type
Interventional
Allocation
Randomized
Ages
50 Years and older
Sex
All
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Study summary

Purpose: There are some controversies about the effect of Levodopa-Carbidopa on treatment of non-arteritic anterior ischemic optic neuropathy (NAION). This study was performed to evaluate the effect of Levodopa-Carbidopa on visual acuity, color vision, and visual field in patients with recent onset NAION (less than 6 weeks duration).

Patients and Methods: In this double-blind randomized clinical trial, 13 patients were treated with levodopa-carbidopa and 12 patients took placebo for 3 weeks. Visual acuity, color vision, and visual field were tested before and at 4th, 12th, 16th, and 24th weeks after enrollment, and evaluated.

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Conditions studied

  • Nonarteritic Anterior Ischemic Optic Neuropathy
03

In context

Optic Nerve Diseases

128 studies on the registry are indexed under Optic Nerve Diseases; 27 are open to participants now.

Browse Optic Nerve Diseases studies →

Lead sponsor

Shahid Beheshti University of Medical Sciences is the lead sponsor of 221 studies on the registry; 19 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
50 Years and older
Sexes eligible
All

Inclusion criteria

  • age greater than 50 years old
  • first ophthalmic examination within 6 weeks after onset of disease
  • presence of optic disc swelling followed by optic atrophy within 6 weeks
  • altitudinal, central or generalized visual field defect
  • normal ESR

Exclusion criteria

Exclusion Criteria:

  • confirmed giant cell arteritis
  • history of any ocular surgeries
  • optic neuropathy due to acute bleeding
  • advanced diabetic retinopathy
  • uncontrolled glaucoma
  • any ocular disorders that cause visual acuity reduction rather than NAION
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Study design

Phase
Phase 4
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double

Interventions

  • Druglevodopa-carbidopa
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Study locations

1 site
  • Ophthalmic research center
    Tehran, 1666694516, Iran, Islamic Republic of
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 20, 2008, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00432393
Lead sponsor
Shahid Beheshti University of Medical Sciences
First posted
Feb 7, 2007
Start date
Jun 2002
Completion
Apr 2003
Last update
Oct 20, 2008

Study contacts

Mohammad Pakravan, MD
principal investigator · Shahid Beheshti University of Medical Sciences
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Feb 2007. You cannot join it, but the record below documents what was studied.

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