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CompletedNCT00428740Updated Jan 30, 2007

Long-Term IOP Fluctuation and VF Progression After Triple Procedure

An observational study in Glaucoma, Filtering Surgery and Intraocular Pressure, sponsored by Yonsei University. Completed at 1 site in Korea, Republic of. Per ClinicalTrials.gov, last updated 2007-01-30.

Sponsored by Yonsei University · Observational

Study type
Observational
Model
Defined population
Time perspective
Retrospective
Enrollment
300
Sex
All
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Study summary

Long-term intraocular pressure (IOP) fluctuation may be significantly associated with the progression of glaucomatous visual field loss, even in patients kept always low IOP after triple procedure, an effective approach for patients with coexisting glaucoma and visually significant cataracts.

Read the detailed description

Previous studies reported that lowering intraocular pressure (IOP) slowed the advancement of visual field damage in glaucoma patients. However, even if the IOP can been substantially lowered, reduction of mean and peak IOP does not always prevent visual field progression.We believe that the long-term IOP fluctuation may play a significant role in visual field deterioration in those patients.

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Conditions studied

  • Glaucoma
  • Filtering Surgery
  • Intraocular Pressure

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In context

Glaucoma

1,818 studies on the registry are indexed under Glaucoma; 231 are open to participants now.

This study's enrollment of 300 is above the median of 103 across 454 observational studies indexed under Glaucoma.

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Lead sponsor

Yonsei University is the lead sponsor of 1,387 studies on the registry; 232 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  1. Underwent triple procedure
  2. At leas 3 years of follow-up after surgery
  3. IOP \<18mmHg at each postoperative visit
  4. A minimum of 5 visual field examinations
  5. A reference visual field defect score of 16 or less
  6. Good reliability indices of visual field

Exclusion criteria

Exclusion Criteria:

  1. Any other significant ocular diseases or intraocular surgical histories,
  2. Diseases that may affect visual field or diabetes
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Study design

Observational model
Defined population
Time perspective
Retrospective
Enrollment
300 participants
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Study locations

1 site
  • Yonsei University College of Medicine
    Seoul, 135-720, Korea, Republic of
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References and documents

Publications

  • Hong S, Seong GJ, Hong YJ. Long-term intraocular pressure fluctuation and progressive visual field deterioration in patients with glaucoma and low intraocular pressures after a triple procedure. Arch Ophthalmol. 2007 Aug;125(8):1010-3. doi: 10.1001/archopht.125.8.1010. PubMed 17698746 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 30, 2007, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00428740
Lead sponsor
Yonsei University
First posted
Jan 30, 2007
Start date
Oct 2005
Completion
Dec 2005
Last update
Jan 30, 2007

Study contacts

Gong Je Seong, MD, PhD
principal investigator · Yondgong Severance Hospital, Yonsei University College of Medicine
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jan 2007. You cannot join it, but the record below documents what was studied.

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