A Phase 4 interventional study of venovenous hemofiltration in Bacteremia, Gram-Negative Bacterial Infections and Gram-Positive Bacterial Infections, sponsored by Hopital Lariboisière. Completed at 1 site in France. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2006-12-04.
Sponsored by Hopital Lariboisière · Phase 4, Interventional, and Supportive care
The impact of continuous veno-venous haemofiltration (CVVH) on sepsis-induced multiple organ failure severity is controversial. We thus sought to assess the effect of early application of haemofiltration on the degree of organ dysfunction and plasma cytokine levels in patients with severe sepsis or septic shock.
prospective, randomized, open, multicentre study was performed between 1997 and 1999 in 16 French intensive care units. Patients were enrolled within 24 hours of development of the first organ failure related to a new septic insult. They were randomized to group 1 (HF), who received haemofiltration for a 96 hr period, or group 2 (C) who were managed conventionally. The primary end-point was the number, severity and duration of organ failures at 14 days, as evaluated by the SOFA score, on an intention-to-treat analysis. Strict guidelines were provided to perform continuous haemofiltration under the same conditions and objectives in all centres.
6,687 studies on the registry are indexed under Infections; 807 are open to participants now.
This study's enrollment of 400 is above the median of 120 across 4,200 interventional studies indexed under Infections.
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The primary end-point was the number, severity and duration of organ failures at 14 days, as evaluated by the SOFA score, on an intention-to-treat analysis
Secondary end point : safety, ventilation and hemodynamic support weaning
This study is completed, as verified in Nov 2006. You cannot join it, but the record below documents what was studied.
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Hopital Lariboisière