An observational study in Lactose Intolerance and Ulcerative Colitis, sponsored by University Hospitals, Leicester. Completed at 1 site in United Kingdom. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2009-02-16.
Sponsored by University Hospitals, Leicester · Observational
The hypothesis underlying this study is that failure to recognise the role of lactose intolerance among patients with ulcerative colitis has led to inappropriate dietary advice and treatment with drugs that contain lactose as a filler. These failures exacerbate symptoms and lead to the unnecessary use of immune suppressant drugs.
There is disagreement amongst researchers regarding the amount of lactose needed to cause symptoms in those who are lactose intolerance. The general consensus is that the amount of lactose in a glass of milk (12 grams) is enough to cause mild symptoms in most patients who are lactose intolerant (1). However, there have been a number of studies and case studies that argue that much lower amounts can cause symptoms (2, 3, 4, 5). This could be as little as 0.02 grams (6).
Ulcerative colitis is a chronic relapsing inflammatory disease of the colon and rectum, characterised by recurrent episodes of abdominal pain and profuse diarrhoea. The prevalence of lactose intolerance in patients with ulcerative colitis is not greater than in the general population, but there is no evidence as to whether these patients are more sensitive to lactose.
This study will identify the threshold at which symptoms of lactose intolerance develop in those who have both lactose intolerance and ulcerative colitis, to provide appropriate advice and treatment in the management of patients with these conditions.
1,073 studies on the registry are indexed under Colitis; 131 are open to participants now.
This study's planned enrollment of 48 is below the median of 105 across 247 observational studies indexed under Colitis.
Browse Colitis studies →University Hospitals, Leicester is the lead sponsor of 67 studies on the registry; 12 are open to participants now.
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Patients with lactose intolerance
Exclusion Criteria:
Dietary Supplement: Lactose in water
Symptoms of pain and diarrhoea
Time frame: Over 48 hours
This study is completed, as verified in Feb 2009. You cannot join it, but the record below documents what was studied.
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University Hospitals, Leicester