A Phase 2 interventional study of aerosolized vancomycin or gentamicin in Ventilator Associated Pneumonia, Respiratory Infection and Tracheobronchitis, sponsored by Stony Brook University. Completed at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2006-11-07.
Sponsored by Stony Brook University · Phase 2, Interventional, and Treatment
The purpose of this study was to determine the effect of aerosolized antibiotics on respiratory infection in mechanically ventilated patients.We hypothesize that aerosolized antibiotics , which achieve high drug concentrations in the airway, would more effectively treat respiratory infection, decrease the need for systemic antibiotics and decrease antibiotic resistance.
In patients requiring mechanical ventilation, signs of respiratory infection often persist despite treatment with powerful antibiotics given through the patient's vein. In this trial, patients with purulent secretions were assigned aerosolized antibiotics or placebo by a randomizing protocol. Neither the patients or their doctors knew what the patient was receiving.Need for a systemic antibiotic was determined by the clinical physician. Comparisons were made between placebo and study drug for their effects on pneumonia, respiratory signs of infection, ability to wean patients from the ventilator, systemic(given in the vein) antibiotic use and the development of organisms that were resistant to antibiotics.
6,687 studies on the registry are indexed under Infections; 807 are open to participants now.
This study's enrollment of 80 is below the median of 120 across 4,200 interventional studies indexed under Infections.
Browse Infections studies →Stony Brook University is the lead sponsor of 191 studies on the registry; 36 are open to participants now.
Of its 22 completed or terminated interventional studies of FDA-regulated products, 10 (45%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Ventilator associated pneumonia Systemic Antibiotic use Clinical pulmonary infection score
Weaning from mechanical ventilation Bacterial resistance
This study is completed, as verified in Nov 2006. You cannot join it, but the record below documents what was studied.
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Stony Brook University