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CompletedNCT00395330Updated Aug 20, 2015

Airways Dysfunction Following WTC Dust Exposure

An observational study in Pulmonary Diseases, sponsored by NYU Langone Health. Completed. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2015-08-20.

Sponsored by NYU Langone Health · Observational

Study type
Observational
Model
Ecologic or community
Time perspective
Retrospective
Enrollment
500
Ages
18 Years to 80 Years
Sex
All
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Study summary

In the weeks following the terrorist attacks of September 11, 2001, many patients presented to their physicians with complaints related to exposure to the debris. These included nose and throat complaints (drip, congestion, sore throat), increased GE reflux (heartburn, regurgitation, retrosternal chest burning) and respiratory symptoms (worsening cough, wheezing, shortness of breath, chest tightness, sleep disturbance). In addition, there was a disproportionate rate of self-reported worsening asthma symptoms in patients living in Lower New York 5-9 weeks after the attack; those with exposure to the dust cloud fared worse. The functional abnormalities of firefighters with exposures to dust at the WTC site has been recently described. However, the effects of WTC dust exposure on pulmonary function in residents and workers near the WTC site remain unclear. This study will retrospectively review the charts of all patients referred to the pulmonary function laboratory for evaluation of symptoms following exposure to WTC dust. The main objectives for this study will be to characterize the functional abnormalities in these subjects.

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Conditions studied

  • Pulmonary Diseases

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Keywords

  • Respiratory Function Tests
  • Oscillometry
  • World Trade Center Disaster
  • Environmental Exposure
  • Distal Airways
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In context

Lung Diseases

3,303 studies on the registry are indexed under Lung Diseases; 355 are open to participants now.

This study's enrollment of 500 is above the median of 157 across 929 observational studies indexed under Lung Diseases.

Browse Lung Diseases studies →

Lead sponsor

NYU Langone Health is the lead sponsor of 1,391 studies on the registry; 254 are open to participants now.

Of its 227 completed or terminated interventional studies of FDA-regulated products, 191 (84%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

study will retrospectively review the charts of all patients referred to the pulmonary function laboratory for evaluation of symptoms following exposure to WTC dust.

Inclusion criteria

  • age 18-80
  • referral for pulmonary function evaluation of respiratory symptoms following exposure to WTC dust

Exclusion criteria

Exclusion Criteria:

  • inability to perform testing
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Study design

Observational model
Ecologic or community
Time perspective
Retrospective
Enrollment
500 participants
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Study locations

No study locations are listed for this record.

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References and documents

Publications

  • Oppenheimer BW, Goldring RM, Herberg ME, Hofer IS, Reyfman PA, Liautaud S, Rom WN, Reibman J, Berger KI. Distal airway function in symptomatic subjects with normal spirometry following World Trade Center dust exposure. Chest. 2007 Oct;132(4):1275-82. doi: 10.1378/chest.07-0913. Epub 2007 Sep 21. PubMed 17890470 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 20, 2015, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00395330
Lead sponsor
NYU Langone Health
First posted
Nov 2, 2006
Start date
Apr 2003
Primary completion
Oct 2006
Completion
Oct 2006
Last update
Aug 20, 2015

Study contacts

Kenneth I Berger, MD
principal investigator · NYU Langone Health
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Aug 2015. You cannot join it, but the record below documents what was studied.

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