Safety Study of MVA Smallpox Vaccine in Subjects With a History of Atopic Dermatitis (AD)

• Adults at least 18 years old and who were born after 1971 with no previous history of smallpox vaccination
• Subjects must be in good general health Female subjects must not be pregnant or lactating and must agree to practice birth control during the course of the study
• Subjects must have a diagnosis of AD by an experienced clinician that includes a history of both major and minor diagnostic criteria
• At the time of screening, the subject must have "mild to moderate" AD.

Exclusion Criteria:

• History or evidence of prior exposure to a vaccinia or MVA- containing product
• known or suspected history of immunodeficiency other than AD
• Known or suspected impairment of major organ function
• Known history or diagnosis of cardiac disease or cerebrovascular disease
• presence of acute, chronic, or active exfoliative skin conditions other than AD, open wounds, or burns.
• Dementia or history of seizures
• Known allergies to MVA or any known components of the vaccine
• transfusion of blood, organ transplantation, or treatment with any blood product
• morbid obesity, or a BMI less than or equal to 18.5
• history of or current drug or alcohol abuse (except nicotine) within the past 6 months or any history of IV drug use
• history of major psychiatric illness except major depression not requiring medical therapy.
• subjects who have participated in another investigational drug or vaccine trial within 30 days of study day 0