An interventional study of non-invasive ventilation in Respiratory Failure, sponsored by Krankenhaus Kloster Grafschaft. Terminated at 1 site in Germany. Open to participants aged 18 Years to 80 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2009-08-11.
Sponsored by Krankenhaus Kloster Grafschaft · Not applicable, Interventional, and Treatment
Measurement of Work of breathing (WOB), as well as pressure time product (PTP) of transdiaphragmatic pressures to evaluate the degree of muscle activity and muscle unloading during non-invasive ventilation.
The study makes comparison of a new developed auto adjusting controlled mode and a regular spontaneous mode.
Non-invasive ventilation (NIV) reduces carbon dioxide in hypercapnic respiratory failure by unloading the respiratory muscles. Spontaneous modes of NIV are usually being used in these situations. Spontaneous modes have the disadvantage, that the patient has to trigger the ventilator. The work to activate the trigger (WT) is estimated to be as high as up to 50% of the total work of breathing dependent on the underlying disease. Elimination of WT would increase the degree of respiratory muscle unloading.
A new pressure controlled mode incorporated into the ventilogic mechanical ventilator (Weinmann, Germany) is capable of self adjusting respiratory parameters in a preset range according to the patient requirements.
After a short period where the patients spontaneous respiratory parameters are being analyzed, the ventilator slowly implements a pressure controlled mode that matches the patients requirements.
This study intends to investigate if this new mode achieves a higher degree of respiratory muscle unloading compared to a spontaneous mode.
1,650 studies on the registry are indexed under Respiratory Insufficiency; 296 are open to participants now.
This study's enrollment of 10 is below the median of 55 across 1,043 interventional studies indexed under Respiratory Insufficiency.
Browse Respiratory Insufficiency studies →Krankenhaus Kloster Grafschaft is the lead sponsor of 6 studies on the registry; none are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Work of breathing, pressure time product
comfort
This study is terminated, as verified in Aug 2009. You cannot join it, but the record below documents what was studied.
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Krankenhaus Kloster Grafschaft