A Phase 2 interventional study of AIC (Amb a 1 Immunostimulatory Conjugate) in Seasonal Allergic Rhinitis, sponsored by Johns Hopkins University. Completed at 1 site in United States. Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2018-12-13.
Sponsored by Johns Hopkins University · Phase 2, Interventional, and Treatment
Various chemical modifications of allergens have been attempted to enhance efficacy, improve safety, and foster compliance with IT. These approaches have been unsuccessful - in that the allergenicity and immunogenicity have either decreased, or increased in tandem, with no resultant efficacy: safety benefit ratio. This study utilizes an adjuvant approach in which synthetic immunostimulatory DNA is conjugated to ragweed allergen in an attempt to modulate both the clinical and immunologic allergic response to ragweed exposure in ragweed-allergic patients with seasonal rhinitis.
Evaluation of efficacy and safety of allergen-CpG oligonucleotide immunostimulatory conjugate in treatment of ragweed-induced seasonal allergic rhinitis. Study incorporates clinical outcomes (symptom diaries, medication diaries, visual analog scores, quality of life questionnaires), safety measurements, immunologic assays (antibody measurements, T-cell assays, cytokine assays, nasal provocation).
1,105 studies on the registry are indexed under Rhinitis; 65 are open to participants now.
This study's enrollment of 25 is below the median of 89 across 906 interventional studies indexed under Rhinitis.
Browse Rhinitis studies →Johns Hopkins University is the lead sponsor of 1,783 studies on the registry; 313 are open to participants now.
Of its 203 completed or terminated interventional studies of FDA-regulated products, 140 (69%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
Effect of treatment on nasal allergen challenge
This study is completed, as verified in Dec 2018. You cannot join it, but the record below documents what was studied.
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Johns Hopkins University