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CompletedNCT00301626Updated Oct 24, 2008

ROSCAP: Reduction of Smoking in Cardiac Patients Study

An interventional study of smoking reduction intervention (including NRT) in Nicotine Dependence, Tobacco Dependence and Cardiac Disease, sponsored by National Institutes of Health (NIH). Completed at 1 site in United States. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2008-10-24.

Sponsored by National Institutes of Health (NIH) · Not applicable and Interventional

Phase
Not applicable
Study type
Interventional
Enrollment
180
Allocation
Randomized
Ages
18 Years to 80 Years
Sex
All
01

Study summary

Background. The ROSCAP Study was a randomized controlled trial in heart disease patients to test the effect of a smoking reduction intervention on cigarettes per day (cpd) and biochemical and clinical indicators of tobacco exposure. .

02

Conditions studied

  • Nicotine Dependence
  • Tobacco Dependence
  • Cardiac Disease

Keywords

  • tobacco
  • nicotine
  • smoking reduction
03

In context

Heart Diseases

3,639 studies on the registry are indexed under Heart Diseases; 461 are open to participants now.

This study's enrollment of 180 is above the median of 100 across 1,778 interventional studies indexed under Heart Diseases.

Browse Heart Diseases studies →

Lead sponsor

National Institutes of Health (NIH) is the lead sponsor of 9 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • smoked at least 15 cigarettes per day and had one of 11 cardiovascular disorders: history of myocardial infarction, coronary artery bypass surgery, angioplasty, stent placement, thrombolytic therapy, angina, arrhythmia, a history of cardiac arrest, greater than 50% coronary artery stenosis by angiography, ischemia on exercise tolerance testing or congestive heart failure, required to confirm that they were unwilling or uninterested in setting a stop smoking date in the next 30 days.

Exclusion criteria

Exclusion Criteria:

    1. unstable angina within the past 2 weeks, 2) unstable psychiatric or substance use disorders or 3) contraindications to nicotine replacement therapy (including pregnancy or intention to become pregnant)
05

Study design

Phase
Not applicable
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
180 participants

Interventions

  • Behavioralsmoking reduction intervention (including NRT)
06

What researchers measure

Primary outcomes

  1. Smoking reduction

Secondary outcomes

  1. Smoking cessation, biomarker measures

07

Study locations

1 site
  • Minneapolis VAMC (111-0)
    Minneapolis, Minnesota 55417, United States
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Oct 24, 2008, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00301626
Lead sponsor
National Institutes of Health (NIH)
First posted
Mar 13, 2006
Start date
Oct 2000
Completion
Jan 2005
Last update
Oct 24, 2008

Study contacts

Anne Joseph, MD, MPH
principal investigator · Minneapolis VAMC & University of Minnesota
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Apr 2005. You cannot join it, but the record below documents what was studied.

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