An interventional study of Simvastatin in Healthy, sponsored by University Hospital, Montpellier. Completed at 1 site in France. Open to male participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2007-08-09.
Sponsored by University Hospital, Montpellier · Not applicable, Interventional, and Treatment
To evaluate the effects of a 8-week treatment with 80 mg/day simvastatin on prooxidant and antioxidant status at rest and after exercise, on mitochondrial respiration and calcium release in skeletal muscle, and on aérobic aptitude in 24 healthy male subjects.
Day 1 : baseline oxidative status, lipid profile, exercice test, start of randomized treatment Day 53 : muscular biopsy Day 57 : follow-up oxidative status, lipid profile, exercice test, end of treatment
280 studies on the registry are indexed under Muscular Diseases; 63 are open to participants now.
This study's planned enrollment of 24 is below the median of 34 across 157 interventional studies indexed under Muscular Diseases.
Browse Muscular Diseases studies →University Hospital, Montpellier is the lead sponsor of 1,244 studies on the registry; 225 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Exclusion Criteria:
-
Blood antioxidant status before treatment and after treatment.
Lipid and protein peroxidation indexes before treatment and after treatment.
In vitro mitochondrial respiration, enzymatic activities and calcium release parameters before treatment and after treatment.
Blood lipids before treatment and after treatment
LDL composition before and after treatment
This study is completed, as verified in Aug 2007. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
University Hospital, Montpellier