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CompletedNCT00263133Updated Jun 4, 2007

Modulation of Visually Evoked Potentials by an Antidepressant

An interventional study of Sertraline in Depression, sponsored by University Hospital Freiburg. Completed at 1 site in Germany. Open to participants aged 18 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2007-06-04.

Sponsored by University Hospital Freiburg · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
12
Allocation
Non-randomized
Ages
18 Years to 65 Years
Sex
All
01

Study summary

12 normal healthy controls will be treated with 50 mg sertraline once daily for three weeks. Early amplitudes of visually evoked potentials will be examined at day 0, 10 and 21 and statistically compared. This study aims to examine a putative modulation of synaptic transmission and plasticity by an antidepressant and is part of a series of studies in healthy individuals and depressed patients.

02

Conditions studied

  • Depression

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Keywords

  • Depression
  • SSRI
  • Sertraline
  • synaptic plasticity
  • visually evoked potentials
03

In context

Depression

8,059 studies on the registry are indexed under Depression; 1,643 are open to participants now.

This study's enrollment of 12 is below the median of 84 across 6,722 interventional studies indexed under Depression.

Browse Depression studies →

Lead sponsor

University Hospital Freiburg is the lead sponsor of 91 studies on the registry; 18 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • healthy individuals 18-65 years

Exclusion criteria

Exclusion Criteria:

  • history of affective oder other psyhiatric disorder
  • severe medical condition
  • pregnancy or ineffective contraception
  • active illicit drug use
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Non-randomized
Intervention model
Single group
Masking
None (open label)
Enrollment
12 participants

Interventions

  • DrugSertraline
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What researchers measure

Primary outcomes

  1. Amplitudes and latencies of early visually evoked potentials.

07

Study locations

1 site
  • Dept. of Psychiatry, University of Freiburg
    Freiburg, 79104, Germany
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 4, 2007, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00263133
Lead sponsor
University Hospital Freiburg
First posted
Dec 7, 2005
Start date
Dec 2005
Completion
Jan 2006
Last update
Jun 4, 2007

Study contacts

Claus Normann, MD
principal investigator · Dept. of Psychiatry, University of Freiburg
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in May 2007. You cannot join it, but the record below documents what was studied.

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