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CompletedNCT00260975Updated Sep 25, 2017

Study of the Effects of Chemotherapy on Memory and Other Mental Functions in Women With Breast Cancer

An observational study in Breast Cancer, sponsored by Ottawa Hospital Research Institute. Completed. Open to female participants aged 50 Years to 65 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2017-09-25.

Sponsored by Ottawa Hospital Research Institute · Observational

Study type
Observational
Model
Cohort
Time perspective
Prospective
Enrollment
112
Ages
50 Years to 65 Years
Sex
Female
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Study summary

Many breast cancer patients treated with chemotherapy complain of problems with concentration and memory. This has been referred to as chemo fog. The current study is investigating this phenomenon by measuring mental function of breast cancer patients prior to and after exposure to chemotherapy, and by comparing mental function in those patients who receive chemotherapy and those who do not.

Read the detailed description

Many breast cancer patients treated with chemotherapy complain of problems with concentration and memory. This has been referred to as chemo fog. The current study will investigate this phenomenon by measuring neuropsychological functioning in early stage breast cancer patients prior to and after exposure to chemotherapy, and by comparing change in cognitive function in patients who receive chemotherapy to similar breast cancer patients receiving hormonal therapy only.

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Conditions studied

  • Breast Cancer

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Keywords

  • breast cancer
  • chemotherapy
  • hormonal therapy
  • cognitive function
  • chemo fog
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In context

Breast Neoplasms

12,544 studies on the registry are indexed under Breast Neoplasms; 2,892 are open to participants now.

This study's enrollment of 112 is below the median of 184 across 2,642 observational studies indexed under Breast Neoplasms.

Browse Breast Neoplasms studies →

Lead sponsor

Ottawa Hospital Research Institute is the lead sponsor of 538 studies on the registry; 100 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
50 Years to 65 Years
Sexes eligible
Female
Accepts healthy volunteers
Yes
Sampling method
Non-probability sample

Study population

Breast Cancer

Inclusion criteria

  • stage I or II breast cancer; woman; 50-65 years old; post-menopausal

Exclusion criteria

Exclusion Criteria:

  • history of previous cancer or chemotherapy; significant neurological or psychiatric history
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Study design

Observational model
Cohort
Time perspective
Prospective
Enrollment
112 participants (actual)

Groups and cohorts

  • Chemotherapy patients

    Breast cancer patients treated with adjuvant chemotherapy of various types.

  • Hormonal patients

    Breast cancer patients treated with adjuvant hormonal therapy but not chemotherapy.

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Study locations

No study locations are listed for this record.

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References and documents

Publications

  • Stewart A, Collins B, Mackenzie J, Tomiak E, Verma S, Bielajew C. The cognitive effects of adjuvant chemotherapy in early stage breast cancer: a prospective study. Psychooncology. 2008 Feb;17(2):122-30. doi: 10.1002/pon.1210. PubMed 17518411 ↗
  • Collins B, Mackenzie J, Stewart A, Bielajew C, Verma S. Cognitive effects of chemotherapy in post-menopausal breast cancer patients 1 year after treatment. Psychooncology. 2009 Feb;18(2):134-43. doi: 10.1002/pon.1379. PubMed 18551510 ↗
  • Collins B, Mackenzie J, Stewart A, Bielajew C, Verma S. Cognitive effects of hormonal therapy in early stage breast cancer patients: a prospective study. Psychooncology. 2009 Aug;18(8):811-21. doi: 10.1002/pon.1453. PubMed 19085975 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 25, 2017, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00260975
Lead sponsor
Ottawa Hospital Research Institute
Collaborators
Canadian Breast Cancer Foundation
Responsible party
Sponsor
First posted
Dec 2, 2005
Start date
Jun 2001
Primary completion
Feb 2008
Completion
Feb 2008
Last update
Sep 25, 2017

Study contacts

Barbara Collins
principal investigator · OHRI

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Sep 2017. You cannot join it, but the record below documents what was studied.

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