A Phase 1/2 interventional study of Neseritide in Acute Kidney Failure, sponsored by Mayo Clinic. Completed at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2009-09-23.
Sponsored by Mayo Clinic · Phase 1/2, Interventional, and Treatment
Use of BNP (nesiritide) vs placebo to help protect kidney function in patients undergoing heart bypass surgery.
This is a randomized, double-blind, placebo controlled study of low dose nesiritide to prevent renal insufficiency after cardiopulmonary bypass surgery. Patients included are those with greater than mild renal insufficiency preoperatively as defined by having a creatinine clearance of less than 50 mL/minute determined by the Cockroft-Gault formula. The infusion of nesiritide (BNP) 0.005 mcg/Kg/minute or placebo begins 1 hour before surgery and runs for 24 hours started after the induction of anesthesia prior to cardiopulmonary bypass.
1,995 studies on the registry are indexed under Renal Insufficiency; 173 are open to participants now.
This study's enrollment of 40 is close to the median of 43 across 1,504 interventional studies indexed under Renal Insufficiency.
Browse Renal Insufficiency studies →Mayo Clinic is the lead sponsor of 3,218 studies on the registry; 670 are open to participants now.
Of its 445 completed or terminated interventional studies of FDA-regulated products, 313 (70%) have results posted.
Counted across the registry records on this site, refreshed daily.
Exclusion criteria:
Dose of Nesiritide infusion will be 0.005 ug/Kg/min
Also known as: BNP, Nesiritide
Creatinine Clearance at 72 hours determined by the Cockroft-Gault formula
Time frame: 72 hours post op
Number of patients requiring dialysis during the hospitalization
Time frame: before hospital discharge
Plasma aldosterone levels at 12 hours and 24 hours
Time frame: 12 hours and 24 hours postoperatively
Total time on ventilator, ICU length of stay, total length of stay in hospital
Time frame: total length of hospital stay
pre and postoperative diuretic dose used
Time frame: pre operative and postoperate
Need or absence of need for inotropic support in the 72 hour perioperative period
Time frame: 72 hours perioperative
This study is completed, as verified in Sep 2009. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Mayo Clinic