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CompletedNCT00251615Updated Aug 6, 2012

Calcium Channel Splice Variant Expression in Cardiovascular Disease and Aging

An observational study in Atherosclerosis, sponsored by National Institute on Aging (NIA). Completed at 1 site in United States. Open to participants aged 21 Years and older. Per ClinicalTrials.gov, last updated 2012-08-06.

Sponsored by National Institute on Aging (NIA) · Observational

Study type
Observational
Model
Cohort
Time perspective
Cross-sectional
Enrollment
18
Ages
21 Years and older
Sex
All
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Study summary

The purpose of this study is to learn what changes in blood vessel contraction may occur as a result of a disease of the vessel that requires surgery. The study will examine the calcium channels present in the vessels being operated on, and the genes that may alter blood vessel function. Possible variation in these genes may change the kind of calcium channels present in blood vessels.

Read the detailed description

The goal of this study is to learn more about how blood vessels function and the mechanism that causes them to contract. The study will investigate the natural history of diseased blood vessel tissue and the calcium channels in the muscle part of the blood vessel. The study will also examine how genetics influences cardiovascular disease and its causes and treatments.

Patients scheduled for vascular surgery will be approached to participate in this study. During surgery, tissue fragments of diseased and marginal tissue will be obtained. A blood sample will be obtained at either the time of surgery or consent and genomic DNA will be extracted.

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Conditions studied

  • Atherosclerosis

Keywords

  • vascular surgery
  • vascular aging
  • arterial aging
  • surgical tissue
  • Aging
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In context

Cardiovascular Diseases

4,904 studies on the registry are indexed under Cardiovascular Diseases; 919 are open to participants now.

This study's enrollment of 18 is below the median of 573 across 1,485 observational studies indexed under Cardiovascular Diseases.

Browse Cardiovascular Diseases studies →

Lead sponsor

National Institute on Aging (NIA) is the lead sponsor of 157 studies on the registry; 13 are open to participants now.

Of its 7 completed or terminated interventional studies of FDA-regulated products, 2 (29%) have results posted.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
21 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Probability sample

Study population

Patients scheduled for vascular surgery

Inclusion criteria

  • Ages 21 and older
  • Scheduled for vascular surgery

Exclusion criteria

Exclusion Criteria:

  • Unwillingness to be subjected to diagnostic and/or therapeutic procedures that are deemed not necessary for clinical management
  • Volunteers deemed too fragile to participate in the study by the principal investigator (PI) or the attending physician
  • Inability to obtain informed consent from either the volunteer or the responsible party (durable power of attorney [DPA]) for the volunteer, with the volunteer's assent
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Study design

Observational model
Cohort
Time perspective
Cross-sectional
Enrollment
18 participants (actual)
Biospecimen retention
Samples with dna
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Study locations

1 site
  • National Institute on Aging, Harbor Hospital
    Baltimore, Maryland 21225, United States
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References and documents

Publications

  • Harry JB, Kobrinsky E, Abernethy DR, Soldatov NM. New short splice variants of the human cardiac Cavbeta2 subunit: redefining the major functional motifs implemented in modulation of the Cav1.2 channel. J Biol Chem. 2004 Nov 5;279(45):46367-72. doi: 10.1074/jbc.M409523200. Epub 2004 Aug 31. PubMed 15339916 ↗
  • Kobrinsky E, Tiwari S, Maltsev VA, Harry JB, Lakatta E, Abernethy DR, Soldatov NM. Differential role of the alpha1C subunit tails in regulation of the Cav1.2 channel by membrane potential, beta subunits, and Ca2+ ions. J Biol Chem. 2005 Apr 1;280(13):12474-85. doi: 10.1074/jbc.M412140200. Epub 2005 Jan 25. PubMed 15671035 ↗
  • Abernethy DR, Soldatov NM. Structure-functional diversity of human L-type Ca2+ channel: perspectives for new pharmacological targets. J Pharmacol Exp Ther. 2002 Mar;300(3):724-8. doi: 10.1124/jpet.300.3.724. PubMed 11861774 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Aug 6, 2012, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00251615
Lead sponsor
National Institute on Aging (NIA)
Responsible party
Sponsor
First posted
Nov 10, 2005
Start date
Aug 2012
Primary completion
Aug 2012
Completion
Aug 2012
Last update
Aug 6, 2012

Study contacts

Samer Najjar, MD
principal investigator · National Institute on Aging (NIA)
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Aug 2012. You cannot join it, but the record below documents what was studied.

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