An observational study in Irritable Bowel Syndrome, sponsored by McMaster University. Completed at 1 site in Canada. Open to participants aged 16 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2009-04-22.
Sponsored by McMaster University · Observational
Acute Bacterial dysentery leads to chronic symptoms of disturbed bowel habit in a minority of individuals. This condition known as post infectious irritable bowel syndrome (PI-IBS) remains poorly understood. This could allow material in the bowel to reach deeper tissues of the bowel wall leading to inflammation and changes in muscle and nerve function. This is also early evidence that genetic programming of people with PI-IBS prevents them from turning off inflammation once it begins. Literature suggests that IBS may develop at greater rates in individuals with pro-inflammatory genotype and that these individuals may be at increased risk of inflammatory bowel diseases (IBD).
This research will study chronic gastrointestinal problems in the residents of Walkerton, Ontario region. Determine whether acute bacterial infection is a risk factor for development of inflammatory bowel disease using the population of Walkerton as a cohort. We hypothesize that exposure to bacterial infection leads to development of post infectious irritable bowel syndrome which is associated with an increase in intestinal permeability and immune activation with low grade intestinal inflammation and that this sequence of events will trigger inflammatory bowel disease in genetically susceptible individuals
1,062 studies on the registry are indexed under Irritable Bowel Syndrome; 190 are open to participants now.
This study's enrollment of 4,561 is above the median of 150 across 178 observational studies indexed under Irritable Bowel Syndrome.
Browse Irritable Bowel Syndrome studies →McMaster University is the lead sponsor of 720 studies on the registry; 124 are open to participants now.
Of its 6 completed or terminated interventional studies of FDA-regulated products, 2 (33%) have results posted.
Counted across the registry records on this site, refreshed daily.
residents of walkerton
Exclusion Criteria:
Unexposed to gastroenteritis
Exposed to gastroenteritis
Number of Participants With Post Infectious Irritable Bowel Syndrome
Time frame: 8 years
Residents of Walkerton in may 2000
| Milestone | Unexposed to Gastroenteritis | Exposed to Gastroenteritis |
|---|---|---|
| Started | 1575 | 2986 |
| Completed | 829 | 1586 |
| Not completed | 746 | 1400 |
| Withdrew: Lost to follow-up | 746 | 1400 |
| participants | Unexposed to Gastroenteritis | Exposed to Gastroenteritis |
|---|---|---|
| Number of Participants With Post Infectious Irritable Bowel Syndrome | 23 | 114 |
| Age, Categorical(Participants) | Unexposed to Gastroenteritis | Exposed to Gastroenteritis | Total |
|---|---|---|---|
| <=18 years | 471 | 907 | 1378.0 |
| Between 18 and 65 years | 905 | 1810 | 2715.0 |
| >=65 years | 199 | 269 | 468.0 |
| Age Continuous(years) | Unexposed to Gastroenteritis | Exposed to Gastroenteritis | Total |
|---|---|---|---|
| Mean | 36.96 ± 22.76 | 34.97 ± 21.61 | 35.66 ± 22.03 |
| Sex: Female, Male(Participants) | Unexposed to Gastroenteritis | Exposed to Gastroenteritis | Total |
|---|---|---|---|
| Female | 892 | 1665 | 2557.0 |
| Male | 683 | 1321 | 2004.0 |
| Region of Enrollment(participants) | Unexposed to Gastroenteritis | Exposed to Gastroenteritis | Total |
|---|---|---|---|
| Canada | 1575 | 2986 | 4561.0 |
This study is completed, as verified in Mar 2009. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
McMaster University