CClinicalTrials.gg
TerminatedNCT00200694Updated Feb 4, 2009

Anti-Proteinuric Response to ACEI, ARB and Diuretics Combination.

A Phase 4 interventional study of ramipril 5 mg + valsartan 80 mg/day, and ramipril 10 mg + valsartan 160 mg/day, in Heavy Proteinuria, sponsored by Nantes University Hospital. Terminated at 1 site in France. Open to participants aged 18 Years to 80 Years. Per ClinicalTrials.gov, last updated 2009-02-04.

Sponsored by Nantes University Hospital · Phase 4 and Interventional

Why this study was terminated
difficulty in patients's inclusion
Phase
Phase 4
Study type
Interventional
Enrollment
18
Allocation
Randomized
Ages
18 Years to 80 Years
Sex
All
01

Study summary

Determine the best strategy for proteinuria lowering in patients with proteinuria > 1 g/day receiving ACEI and ARB combination: either increase of ACEI and ARB dosage or increase of diuretic dosage.

02

Conditions studied

  • Heavy Proteinuria

Browse trials for

Keywords

  • Proteinuria
  • ACEI
  • ARB
  • diuretics
  • blood pressure
  • renal failure
03

In context

Proteinuria

234 studies on the registry are indexed under Proteinuria; 43 are open to participants now.

This study's enrollment of 18 is below the median of 60 across 164 interventional studies indexed under Proteinuria.

Browse Proteinuria studies →

Lead sponsor

Nantes University Hospital is the lead sponsor of 825 studies on the registry; 195 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 80 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • proteinuria > 1 g/day with ramipril 5 + valsartan 80 mg/day for 2 months
  • proteinuria changes \< 50% on 3 separate dosages over 2 months.

Exclusion criteria

Exclusion criteria:

  • age \< 18 or > 80 years systolic BP \< 110 or ≥ 140 mmHg, serum creatinine > 250 mmole/L
  • serum creatinine increase on ramipril + valsartan > 20%
  • intolerance to ACEI or ARB
05

Study design

Phase
Phase 4
Allocation
Randomized
Intervention model
Crossover assignment
Masking
None (open label)
Enrollment
18 participants

Interventions

  • Drugramipril 5 mg + valsartan 80 mg/day,
  • Drugramipril 10 mg + valsartan 160 mg/day,
  • Drugramipril 5 mg + valsartan 80 mg/day + increased dosage of furosémide.
06

Study locations

1 site
  • CHU de Nantes
    Nantes, France
07

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 4, 2009, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
08

Registry details

Key details

Study ID
NCT00200694
Lead sponsor
Nantes University Hospital
First posted
Sep 20, 2005
Start date
Mar 2005
Primary completion
Mar 2007
Completion
Mar 2007
Last update
Feb 4, 2009

Study contacts

Vincent LM Esnault, MD PHD
principal investigator · Nantes University Hospital
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is terminated, as verified in Feb 2009. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion