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CompletedNCT00197886Updated Sep 20, 2006

Dose of Norepinephrine and the Concentration of L-Lactate in the Rectum and Stomach in Patients With Septic Shock.

An interventional study of Changing dose of norepinephrine and blood pressure in Septic Shock, sponsored by Herlev Hospital. Completed at 1 site in Denmark. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2006-09-20.

Sponsored by Herlev Hospital · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
10
Allocation
Randomized
Ages
18 Years and older
Sex
All
01

Study summary

Norepinephrine is a drug used to increase blood pressure in patients with life-threatening infection. However, norepinephrine may limit the bloodflow to the gut, thereby causing relative lack of oxygen to the cells. This leads to increased formation of lactic acid.

This study examines whether increasing the dose of norepinephrine leads to higher concentrations of lactic acid in the rectum and stomach in patients with life-threatening infection.

02

Conditions studied

  • Septic Shock

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03

In context

Shock, Septic

862 studies on the registry are indexed under Shock, Septic; 207 are open to participants now.

This study's enrollment of 10 is below the median of 80 across 530 interventional studies indexed under Shock, Septic.

Browse Shock, Septic studies →

Lead sponsor

Herlev Hospital is the lead sponsor of 195 studies on the registry; 25 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Septic shock
  • NE-dose > 0.1 microg/kg/min
  • CI > 3.0 l/min/m2

Exclusion criteria

Exclusion Criteria:

  • Age \< 18, unable to obtain informed consent from relatives
  • Untreated hypertension
  • Pregnancy
  • Pathology in the rectum or stomach
  • Limitation of therapy
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Crossover assignment
Masking
Single
Enrollment
10 participants

Interventions

  • DrugChanging dose of norepinephrine and blood pressure
06

What researchers measure

Primary outcomes

  1. L-lactate concentration in the rectum and stomach.

07

Study locations

1 site
  • Dept. of Intensive Care, Herlev University Hospital
    Herlev, 2730, Denmark
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 20, 2006, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00197886
Lead sponsor
Herlev Hospital
First posted
Sep 20, 2005
Start date
Oct 2004
Completion
Dec 2005
Last update
Sep 20, 2006

Study contacts

Anders Perner, MD,PhD
study chair · Dept. of Anaesthesia and Intensive Care, Herlev University Hospital, DK-2730 Herlev
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Sep 2006. You cannot join it, but the record below documents what was studied.

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