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CompletedNCT00192764Updated Sep 22, 2010

High Dose CHOP in Lymphoma

A Phase 2 interventional study of high-dose cyclophosphamide in Non-Hodgkin's Lymphoma, sponsored by Rambam Health Care Campus. Completed at 1 site in Israel. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2010-09-22.

Sponsored by Rambam Health Care Campus · Phase 2, Interventional, and Treatment

Phase
Phase 2
Study type
Interventional
Enrollment
45
Allocation
Non-randomized
Ages
18 Years to 65 Years
Sex
All
01

Study summary

The study hypothesis is that intensification of CHOP by dose escalation of the most active drugs in the combination will improve treatment outcome. Patients with diffuse large-cell lymphoma are treated by high cyclophosphamide containing CHOP. The planned dose is 3000 mg/m2 which is 4 times the atandard one. Only 4 cycles are given.

02

Conditions studied

  • Non-Hodgkin's Lymphoma

Keywords

  • large cell lymphoma
  • CHOP
  • cyclophosphamide
  • high-dose
03

In context

Lymphoma

5,578 studies on the registry are indexed under Lymphoma; 825 are open to participants now.

This study's enrollment of 45 is above the median of 40 across 4,508 interventional studies indexed under Lymphoma.

Browse Lymphoma studies →

Lead sponsor

Rambam Health Care Campus is the lead sponsor of 456 studies on the registry; 33 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • large-cell non-Hodgkin's lymphoma
  • IPI low-intermediate, high-intermediate and high or bulky mediastinum
  • age 18-65

Exclusion criteria

Exclusion Criteria:

  • previous treatment for lymphoma
  • serious concurrent systemic disease
05

Study design

Phase
Phase 2
Primary purpose
Treatment
Allocation
Non-randomized
Intervention model
Single group
Masking
None (open label)
Enrollment
45 participants

Interventions

  • Drughigh-dose cyclophosphamide
06

What researchers measure

Primary outcomes

  1. Failure-free survival

Secondary outcomes

  1. overall survival

  2. response rate

  3. toxicity

07

Study locations

1 site
  • Department of Oncology, Rambam Medical Center
    Haifa, Israel
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Sep 22, 2010, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00192764
Lead sponsor
Rambam Health Care Campus
First posted
Sep 19, 2005
Start date
Dec 1996
Completion
Sep 2010
Last update
Sep 22, 2010

Study contacts

Ron Epelbaum, MD
principal investigator · nonaffiliated
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Sep 2010. You cannot join it, but the record below documents what was studied.

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