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CompletedNCT00192712Updated Nov 10, 2010

Irinotecan, Gemcitabine and Radiation Therapy for Pancreatic Cancer

A Phase 2/3 interventional study of irinotecan, gemcitabine in Pancreatic Cancer, sponsored by Rambam Health Care Campus. Completed at 1 site in Israel. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2010-11-10.

Sponsored by Rambam Health Care Campus · Phase 2/3, Interventional, and Treatment

Phase
Phase 2/3
Study type
Interventional
Enrollment
20
Allocation
Non-randomized
Ages
18 Years and older
Sex
All
01

Study summary

The study hypothesis is that chemoradiation based on 2 drugs will improve local control and long-term survival in patients with locally advanced pancreatic cancer. That is why gemcitabine and irinotecan are combined in an induction phase of 2 months and then this IrinoGem combination is given for 3 more cycles, in reduced doses,concurently with irradiation.

02

Conditions studied

  • Pancreatic Cancer

Keywords

  • carcinoma
  • pancreas
  • chemotherapy
  • radiotherapy
03

In context

Pancreatic Neoplasms

3,235 studies on the registry are indexed under Pancreatic Neoplasms; 899 are open to participants now.

This study's enrollment of 20 is below the median of 46 across 2,424 interventional studies indexed under Pancreatic Neoplasms.

Browse Pancreatic Neoplasms studies →

Lead sponsor

Rambam Health Care Campus is the lead sponsor of 456 studies on the registry; 33 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • locally advanced pancreatic cancer
  • performance status 0-2
  • normal blood count and chemistry
  • no previous chemotherapy or radiotherapy

Exclusion criteria

Exclusion Criteria:

  • serious concurrent systemic disease
05

Study design

Phase
Phase 2 / Phase 3
Primary purpose
Treatment
Allocation
Non-randomized
Intervention model
Single group
Masking
None (open label)
Enrollment
20 participants

Interventions

  • Drugirinotecan, gemcitabine
06

What researchers measure

Primary outcomes

  1. time to treatment failure

Secondary outcomes

  1. response rate, survival, toxicity

07

Study locations

1 site
  • Department of Oncology, Rambam Medical Center
    Haifa, 31096, Israel
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Nov 10, 2010, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00192712
Lead sponsor
Rambam Health Care Campus
First posted
Sep 19, 2005
Start date
Nov 2002
Completion
Sep 2010
Last update
Nov 10, 2010

Study contacts

Ron Epelbaum, MD
principal investigator
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Sep 2010. You cannot join it, but the record below documents what was studied.

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