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CompletedNCT00186433Updated May 27, 2015

A Longitudinal Study of Plasma EBV DNA in Nasopharyngeal Carcinoma From Both Endemic and Non-Endemic Patient Populations

An observational study in Mouth Cancer, Lip Cancer and Throat Cancer, sponsored by Stanford University. Completed at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2015-05-27.

Sponsored by Stanford University · Observational

Study type
Observational
Model
Case-control
Time perspective
Prospective
Enrollment
49
Ages
18 Years and older
Sex
All
01

Study summary

  1. To determine the prognostic implication of plasma Epstein-Bar Virus (EBV) DNA concentrations, as measured by quantitative polymerase chain reaction (PCR) in patients with nasopharyngeal carcinoma (NPC).
  2. To relate pretreatment plasma EBV DNA concentration to WHO classification of these tumors both in endemic and non-endemic areas.
  3. To determine whether pretreatment plasma EBV DNA can serve as a prognostic factor for both endemic and non-endemic patient populations.
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Conditions studied

  • Mouth Cancer
  • Lip Cancer
  • Throat Cancer
  • Lip Neoplasms
  • Head and Neck Cancers
03

In context

Mouth Neoplasms

381 studies on the registry are indexed under Mouth Neoplasms; 126 are open to participants now.

This study's enrollment of 49 is below the median of 88 across 104 observational studies indexed under Mouth Neoplasms.

Browse Mouth Neoplasms studies →

Lead sponsor

Stanford University is the lead sponsor of 2,161 studies on the registry; 428 are open to participants now.

Of its 268 completed or terminated interventional studies of FDA-regulated products, 207 (77%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

Having a new diagnosis of Nasopharyngeal carcinoma

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Having a new diagnosis of Nasopharyngeal carcinoma.
  • Being treated with either radiotherapy or chemoradiotherapy for this condition.

Exclusion criteria

Exclusion Criteria:

  • Age \<18 since NPC is a very rare condition in this age group and may have a different biological behavior
  • Patients who are unable to provide informed consents for themselves.
05

Study design

Observational model
Case-control
Time perspective
Prospective
Enrollment
49 participants (actual)
Biospecimen retention
Samples with dna
06

What researchers measure

Primary outcomes

  1. Plasma Epstein-Bar Virus (EBV) DNA concentrations

    measured by quantitative polymerase chain reaction (PCR)

    Time frame: every 6 months until end of study

07

Study locations

1 site
  • Stanford University School of Medicine
    Stanford, California 94305, United States
08

References and documents

Publications

  • Le QT, Zhang Q, Cao H, Cheng AJ, Pinsky BA, Hong RL, Chang JT, Wang CW, Tsao KC, Lo YD, Lee N, Ang KK, Chan AT, Chan KC. An international collaboration to harmonize the quantitative plasma Epstein-Barr virus DNA assay for future biomarker-guided trials in nasopharyngeal carcinoma. Clin Cancer Res. 2013 Apr 15;19(8):2208-15. doi: 10.1158/1078-0432.CCR-12-3702. Epub 2013 Mar 4. PubMed 23459720 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 27, 2015, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00186433
Responsible party
Quynh-Thu Le (Katharine Dexter McCormick and Stanley McCormick Memorial Professor, Stanford University) — Principal investigator
First posted
Sep 16, 2005
Start date
Nov 2001
Primary completion
Jun 2013
Completion
Jun 2013
Last update
May 27, 2015

Study contacts

Quynh-Thu Le
principal investigator · Stanford University

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in May 2015. You cannot join it, but the record below documents what was studied.

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