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Status unknownNCT00175630Updated Jun 1, 2016

The Effect of Femoral Nerve Block on Postoperative Opioid Use After Anterior Cruciate Ligament (ACL) Reconstruction

A Phase 1 interventional study of Administration of a femoral nerve block (bupivacaine HCL) in Pain, Postoperative, sponsored by University of British Columbia. Status unknown at 1 site in Canada. Open to participants aged 12 Years to 17 Years. Per ClinicalTrials.gov, last updated 2016-06-01.

Sponsored by University of British Columbia · Phase 1, Interventional, and Treatment

The sponsor has not verified this record recently (last verified May 2016), so the status shown — last known as Active, not recruiting — may be out of date.
Phase
Phase 1
Study type
Interventional
Enrollment
30
Allocation
Randomized
Ages
12 Years to 17 Years
Sex
All
01

Study summary

This study evaluates the effect of a femoral nerve block on opioid requirements following anterior cruciate ligament (ACL) reconstruction. This is a double blind, prospective randomized controlled trial.

02

Conditions studied

  • Pain, Postoperative

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Keywords

  • ACL reconstruction
  • morphine sparing
  • preemptive analgesia
  • Post-operative pain and post- operative opioid use
03

In context

Pain, Postoperative

5,093 studies on the registry are indexed under Pain, Postoperative; 1,140 are open to participants now.

This study's enrollment of 30 is below the median of 75 across 4,344 interventional studies indexed under Pain, Postoperative.

Browse Pain, Postoperative studies →

Lead sponsor

University of British Columbia is the lead sponsor of 1,309 studies on the registry; 253 are open to participants now.

Of its 6 completed or terminated interventional studies of FDA-regulated products, 1 (17%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
12 Years to 17 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Schedule for primary elective anterior cruciate ligament reconstruction
  • Tolerance to bupivacaine
  • Tolerance to non-steroidal anti-inflammatory drugs (NSAIDs)
  • Informed consent

Exclusion criteria

Exclusion Criteria:

  • Patients who received a femoral nerve block more than 1 hour prior to surgery
  • Complex associated injuries or pre-existing conditions that will delay time to ambulation
  • Children with tibial avulsion fractures
  • Allergic and/or sensitive to bupivacaine and/or NSAIDs
  • 30% over ideal body weight
  • Acute ACL reconstruction (done less than 2 weeks after injury)
  • Pre-existing femoral nerve injury
  • Psychiatric patients on psychotropic agents
  • History of drug or alcohol dependence or recreational drug use
  • Refusal to provide informed consent
05

Study design

Phase
Phase 1
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Investigator)
Enrollment
30 participants (actual)

Interventions

  • ProcedureAdministration of a femoral nerve block (bupivacaine HCL)

    See Detailed Description

06

What researchers measure

Primary outcomes

  1. Postoperative morphine requirement

Secondary outcomes

  1. Pain rating

    Time frame: immediately post-op

  2. Opioid surgical time

    Time frame: time from end of anaesthesia to first requirement of morphine

07

Study locations

1 site
  • British Columbia Children's Hospital, Department of Orthopaedics
    Vancouver, British Columbia V6H 3V4, Canada
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 1, 2016, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00175630
Lead sponsor
University of British Columbia
Responsible party
Sponsor
First posted
Sep 15, 2005
Start date
Dec 2010
Primary completion
Sep 2011
Completion
Sep 2016 (estimated)
Last update
Jun 1, 2016

Study contacts

Christopher Reilly, MD
principal investigator · University of British Columbia

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in May 2016. You cannot join it, but the record below documents what was studied.

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