ClinicalTrials.gg
Status unknownNCT00168285Updated Apr 5, 2007

Pulmonary Rehabilitation in Interstitial Lung Disease

An interventional study of Pulmonary Rehabilitation in Interstitial Lung Disease, sponsored by The Alfred. Status unknown at 2 sites in Australia. Open to participants aged 40 Years to 90 Years. Per ClinicalTrials.gov, last updated 2007-04-05.

Sponsored by The Alfred · Not applicable, Interventional, and Treatment

The sponsor has not verified this record recently (last verified Apr 2007), so the status shown — last known as Active, not recruiting — may be out of date.
Phase
Not applicable
Study type
Interventional
Enrollment
56
Allocation
Randomized
Ages
40 Years to 90 Years
Sex
All
01

Study summary

Interstitial lung disease (ILD) is a highly disabling group of conditions including idiopathic pulmonary fibrosis (IPF), acute and chronic interstitial pneumonias, connective tissue diseases and sarcoidosis. People with ILD frequently experience breathlessness on exertion, which limits their ability to undertake daily activities. People with ILD report very poor quality of life due to low levels of physical functioning and vitality, and high levels of breathlessness and fatigue. There are few treatments for ILD and those that are available have limited impact on quality of life.

The aim of this study is to assess the effects of Pulmonary Rehabilitation, which consists of specialised exercise training for people with lung disease, on exercise capacity and quality of life in people with ILD. We hypothesis that exercise training will result in reduced dyspnoea, improved exercise tolerance and enhanced quality of life.

Read the detailed description

Interstitial lung disease (ILD) is a highly disabling group of conditions including idiopathic pulmonary fibrosis (IPF), acute and chronic interstitial pneumonias, connective tissue diseases and sarcoidosis. People with ILD frequently experience breathlessness on exertion, which limits their ability to undertake daily activities and reduces health-related quality of life.Available treatments for ILD have proved largely ineffective, offering no improvement in survival and demonstrating only limited impact on quality of life.

Aims of the Research

  1. Evaluate the effects of Pulmonary Rehabilitation on exercise capacity and quality of life in patients with ILD
  2. Determine the physiological response to Pulmonary Rehabilitation in patients with ILD
  3. Determine the relationship between the aetiology and severity of ILD and the effects of Pulmonary Rehabilitation.

Comparisons: 8 weeks exercise training compared to control group (maximal exercise capacity, functional exercise capacity, dyspnoea, quality of life).

02

Conditions studied

  • Interstitial Lung Disease

Keywords

  • Exercise
  • Pulmonary rehabilitation
  • Idiopathic pulmonary fibrosis
  • Connective tissue disorders
03

In context

Lung Diseases, Interstitial

656 studies on the registry are indexed under Lung Diseases, Interstitial; 241 are open to participants now.

This study's enrollment of 56 is close to the median of 57 across 362 interventional studies indexed under Lung Diseases, Interstitial.

Browse Lung Diseases, Interstitial studies →

Lead sponsor

The Alfred is the lead sponsor of 47 studies on the registry; 4 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
40 Years to 90 Years
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Ambulant
  • Stable medical therapy
  • Dyspnoea on exertion following maximal treatment

Exclusion criteria

Exclusion Criteria:

  • A history of syncope on exertion
  • Too unwell to attend the hospital for exercise training
  • Any other comorbidities which would prevent exercise training
  • Previous Pulmonary Rehabilitation in the last 12 months
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Single
Enrollment
56 participants

Interventions

  • BehavioralPulmonary Rehabilitation
06

What researchers measure

Primary outcomes

  1. Functional exercise capacity

Secondary outcomes

  1. Maximal exercise capacity

  2. Health-related quality of life

  3. Dyspnoea

07

Study locations

2 sites
  • Alfred Hospital
    Melbourne, Victoria 3004, Australia
  • Austin Hospital
    Melbourne, Victoria 3084, Australia
08

References and documents

Publications

  • Holland AE, Hill CJ, Conron M, Munro P, McDonald CF. Short term improvement in exercise capacity and symptoms following exercise training in interstitial lung disease. Thorax. 2008 Jun;63(6):549-54. doi: 10.1136/thx.2007.088070. Epub 2008 Feb 1. PubMed 18245143 ↗
09

Timeline

Tracking since Sep 25, 2026
Not marked actual or estimatedDates not marked actual or estimated

The record gives a start of Mar 2005 and a completion of May 2007. It does not say whether these dates are actual or estimated.

How these figures are worked out, and which studies are left out of them.

Registered
Sep 13, 2005
First posted
Sep 15, 2005
Start
Mar 2005
CompletionEst.
May 2007
Last update
Apr 5, 2007
What these dates mean
Start.
When the first participant enrolled; while estimated, when the study expects to open to recruitment.
Completion.
When the last participant's last visit took place, for every outcome, secondary ones and side effects included: the end of the study. Often later than primary completion, sometimes the same day.
Actual and Est.
Actual means the registry says the date has happened. Est. (estimated) is a date the sponsor plans or expects. It can still move, and the sponsor is expected to change it to actual once it has passed.
No changes since tracking began. The registry record was last updated on Apr 5, 2007, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT00168285
Lead sponsor
The Alfred
Collaborators
La Trobe University, Austin Hospital, Melbourne Australia, Victorian Tuberculosis and Lung Association
First posted
Sep 15, 2005
Start date
Mar 2005
Completion
May 2007 (estimated)
Last update
Apr 5, 2007

Study contacts

Anne E Holland, PhD
principal investigator · Alfred Hospital and LaTrobe University
Matthew Conron, MBBS
principal investigator · The Alfred
Prue Munro, BAppSc
principal investigator · The Alfred
Christine McDonald, MBBS PhD
principal investigator · Austin Hospital, Melbourne Australia
Catherine Hill, PhD
principal investigator · Austin Hospital, Melbourne Australia

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is status unknown, as verified in Apr 2007. You cannot join it, but the record below documents what was studied.

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