CClinicalTrials.gg
CompletedNCT00166322Updated May 7, 2008

Dopaminergic Neurotransmission in Schizophrenia, Patients at Risk and Healthy Subjects

An interventional study of IBZM-SPECT (bolus and constant infusion paradigm) in Schizophrenia, sponsored by Ludwig-Maximilians - University of Munich. Completed at 2 sites in Germany. Open to participants aged 18 Years to 70 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2008-05-07.

Sponsored by Ludwig-Maximilians - University of Munich · Not applicable, Interventional, and Diagnostic

Phase
Not applicable
Study type
Interventional
Enrollment
35
Allocation
Non-randomized
Ages
18 Years to 70 Years
Sex
All
01

Study summary

This study is an investigation of the dopaminergic neurotransmission in patients with schizophrenia, patients at risk for the development of schizophrenia, and healthy controls using an iodobenzamide-single photon emission computed tomography (IBZM-SPECT) imaging technique under amphetamine challenge.

02

Conditions studied

  • Schizophrenia

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Keywords

  • IBZM-SPECT
  • Amphetamine Challenge
  • Schizophrenia
  • dopaminergic neurotransmission
  • Persons at risk for the development of schizophrenia
  • healthy subjects
03

In context

Schizophrenia

3,470 studies on the registry are indexed under Schizophrenia; 471 are open to participants now.

This study's enrollment of 35 is below the median of 70 across 2,871 interventional studies indexed under Schizophrenia.

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Lead sponsor

Ludwig-Maximilians - University of Munich is the lead sponsor of 218 studies on the registry; 29 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 70 Years
Sexes eligible
All
Accepts healthy volunteers
Yes

Inclusion criteria

  • Clinical diagnosis of schizophrenia (currently unmedicated)
  • Subjects at risk for the development of schizophrenia (prodromal symptoms)
  • Healthy subjects
  • Written informed consent

Exclusion criteria

Exclusion Criteria:

  • Neurological or severe somatic disorders
  • Women during pregnancy or lactation
  • Occupational exposition to radiation > 15mSv
  • Medication known to interfere with IBZM
  • Contraindications for the use of amphetamine challenge
05

Study design

Phase
Not applicable
Primary purpose
Diagnostic
Allocation
Non-randomized
Intervention model
Single group
Masking
None (open label)
Enrollment
35 participants (actual)

Interventions

  • ProcedureIBZM-SPECT (bolus and constant infusion paradigm)

    single IBZM-SPECT assessment at study inclusion

06

What researchers measure

Primary outcomes

  1. dopamine receptor availability

    Time frame: cross-sectional

07

Study locations

2 sites
  • Dept. of Psychiatry
    Munich, D-80336, Germany
  • Dept. of Nuclear Medicine
    Munich, D-81377, Germany
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 7, 2008, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00166322
Lead sponsor
Ludwig-Maximilians - University of Munich
First posted
Sep 14, 2005
Start date
Jan 2004
Primary completion
Dec 2007
Completion
Dec 2007
Last update
May 7, 2008

Study contacts

Oliver Pogarell, MD
principal investigator · Dept. of Psychiatry, University of Munich
Klaus Tatsch, MD
principal investigator · Dept. of Nuclear Medicine, University of Munich
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in May 2008. You cannot join it, but the record below documents what was studied.

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