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CompletedNCT00159770Updated Feb 21, 2021

Effect And Safety Of Ziprasidone Compared To Other Atypical Antipsychotic Drug In Schizophrenic Patients

A Phase 3 interventional study of ziprasidone versus olanzapine , risperidone or quetiapine and Panss , CGI-C, UKU-SERS-Pa in Schizophrenia, Schizoaffective Disorder and Psychotic Disorders, sponsored by Pfizer's Upjohn has merged with Mylan to form Viatris Inc.. Completed at 43 sites in 4 countries. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2021-02-21.

Sponsored by Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (part of Viatris Inc.) · Phase 3, Interventional, and Treatment

Phase
Phase 3
Study type
Interventional
Enrollment
290
Allocation
Randomized
Ages
18 Years and older
Sex
All
01

Study summary

Evaluation of the antipsychotic efficacy and safety of ziprasidone versus olanzapine, risperidone or quetiapine in patients with schizophrenia, schizoaffective and schizophreniform disorders under naturalistic conditions of clinical practice

02

Conditions studied

  • Schizophrenia
  • Schizoaffective Disorder
  • Psychotic Disorders
03

In context

Schizophrenia

3,539 studies on the registry are indexed under Schizophrenia; 473 are open to participants now.

This study's enrollment of 290 is above the median of 70 across 2,924 interventional studies indexed under Schizophrenia.

Browse Schizophrenia studies →

Lead sponsor

Pfizer's Upjohn has merged with Mylan to form Viatris Inc. is the lead sponsor of 434 studies on the registry; none are open to participants now.

Of its 9 completed or terminated interventional studies of FDA-regulated products, 8 (89%) have results posted.

First submitted before Pfizer's Upjohn has merged with Mylan to form Viatris Inc. became part of Viatris Inc..

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • Inpatients or outpatients with schizophrenia, schizoaffective and schizophreniform disorders (DSM-IV).
  • Patients without adequate current treatment (i.e. intolerance to their current treatment or lack of efficacy of current treatment) based on clinical judgement of the investigator

Exclusion criteria

Exclusion Criteria:

  • A history of intolerance to ziprasidone, olanzapine, risperidone or quetiapine or any of its ingredients
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Study design

Phase
Phase 3
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
None (open label)
Enrollment
290 participants

Interventions

  • Drugziprasidone versus olanzapine , risperidone or quetiapine
  • BehavioralPanss , CGI-C, UKU-SERS-Pa
  • ProcedureBlood tests
06

What researchers measure

Primary outcomes

  1. PANSS (The Positive And Negative Syndrome Scale) in a 12 week period

Secondary outcomes

  1. CGI-C score (Clinical Global Impression of Change), UKU-SERS-Pa (Patient self rating version). Safety and tolerability: ECG, serum cholesterol, triglycerides, prolactin, glucose and body weight

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Study locations

43 sites
  • Pfizer Investigational Site
    Aalborg, 9100, Denmark
  • Pfizer Investigational Site
    Arhus C, 8000, Denmark
  • Pfizer Investigational Site
    Augustenborg, 6440, Denmark
  • Pfizer Investigational Site
    Ballerup Municipality, 2750, Denmark
  • Pfizer Investigational Site
    Brovst, 9460, Denmark
  • Pfizer Investigational Site
    Copenhagen, 2100, Denmark
  • Pfizer Investigational Site
    Dianalund, 4293, Denmark
  • Pfizer Investigational Site
    Esbjerg, 6700, Denmark
  • Pfizer Investigational Site
    Esbjerg N, 6715, Denmark
  • Pfizer Investigational Site
    Glostrup Municipality, 2600, Denmark
  • Pfizer Investigational Site
    Haderslev, 6100, Denmark
  • Pfizer Investigational Site
    Holbæk, 4300, Denmark
  • Pfizer Investigational Site
    Kjellerup, 8620, Denmark
  • Pfizer Investigational Site
    Kolding, 6000, Denmark
  • Pfizer Investigational Site
    København S, 2300, Denmark
  • Pfizer Investigational Site
    Lemvig, 7620, Denmark
  • Pfizer Investigational Site
    Odense C, 5000, Denmark
  • Pfizer Investigational Site
    Ringkøbing, 6950, Denmark
  • Pfizer Investigational Site
    Risskov, 8240, Denmark
  • Pfizer Investigational Site
    Vejle, 7100, Denmark
  • Pfizer Investigational Site
    Viborg, 8800, Denmark
  • Pfizer Investigational Site
    Vordingborg, 4760, Denmark
  • Pfizer Investigational Site
    Forssa, 30101, Finland
  • Pfizer Investigational Site
    Helsinki, 00099, Finland
  • Pfizer Investigational Site
    Jarvenpaa, 04400, Finland
  • Pfizer Investigational Site
    Kiviranta, 95410, Finland
  • Pfizer Investigational Site
    Mikkeli, 50520, Finland
  • Pfizer Investigational Site
    Turku, 20700, Finland
  • Pfizer Investigational Site
    Tuusula, 04301, Finland
  • Pfizer Investigational Site
    Reykjavik, 101, Iceland
  • Pfizer Investigational Site
    Basel, Canton of Basel-City CH-4025, Switzerland
  • Pfizer Investigational Site
    Bern, Canton of Bern CH-3000, Switzerland
  • Pfizer Investigational Site
    Sankt Gallen, Canton of St. Gallen 9000, Switzerland
  • Pfizer Investigational Site
    Lausanne, Canton of Vaud 1003, Switzerland
  • Pfizer Investigational Site
    Prangins, Canton of Vaud 1197, Switzerland
  • Pfizer Investigational Site
    Zurich, Canton of Zurich 8029, Switzerland
  • Pfizer Investigational Site
    Bulle, CH - 1630, Switzerland
  • Pfizer Investigational Site
    Chêne-Bourg, 1225, Switzerland
  • Pfizer Investigational Site
    Delémont, CH-2800, Switzerland
  • Pfizer Investigational Site
    Oetwil, CH-8618, Switzerland
  • Pfizer Investigational Site
    Riehen, 4125, Switzerland
  • Pfizer Investigational Site
    Saint Urban, 4915, Switzerland
  • Pfizer Investigational Site
    Solothurn, CH-4503, Switzerland
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 21, 2021, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00159770
Responsible party
Sponsor
First posted
Sep 12, 2005
Start date
Nov 2001
Completion
Sep 2004
Last update
Feb 21, 2021

Study contacts

Pfizer CT.gov Call Center
study director · Pfizer
View the source record on ClinicalTrials.gov ↗

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This study is completed, as verified in Feb 2021. You cannot join it, but the record below documents what was studied.

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