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CompletedNCT00119977Updated Feb 12, 2008

Periacetabular Osteotomy.A Prospective Study With Reference to Cartilage, Migration and Bone Density

An interventional study of 1 Periacetabular osteotomy in Osteoarthritis, sponsored by University of Aarhus. Completed at 1 site in Denmark. Open to participants aged 18 Years to 60 Years. Per ClinicalTrials.gov, last updated 2008-02-12.

Sponsored by University of Aarhus · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
35
Allocation
Non-randomized
Ages
18 Years to 60 Years
Sex
All
01

Study summary

The purpose of this study is to evaluate the effect of performing a periacetabular osteotomy on patients with hip dysplasia.

Read the detailed description

The cause of osteoarthritis in hip dysplasia is thought to be attributable to increased joint contact pressures secondary to decreased acetabular coverage of the femoral head and/or incongruity of the articular surfaces. The investigators' hypothesis is that when periacetabular osteotomy is performed and contact pressure on cartilage reduced, additional joint degeneration will be slowed or prevented unless irreparable damage to the cartilage has happened at the time periacetabular osteotomy is performed. Hence, the purposes of this study are:

  • to develop an unbiased and precise method for measurement of the thickness of the articular cartilage in the hip joint because such a method can be used to evaluate the effect of periacetabular osteotomy and also to give a more precise indication/contraindication for surgery;
  • to evaluate the migration of the acetabulum postoperatively and 6 months after surgery by use of RSA to examine the stability of the osteotomy; and
  • to examine bone mineral density in acetabulum 1 and 2 years after surgery in order to find out whether the change in load distribution will affect bone density of the acetabulum over time in a way that in the area where more load is applied, bone density will increase, and in areas with less load, bone density will decrease;
  • to examine the labrum in the hip joint.
02

Conditions studied

  • Osteoarthritis

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Keywords

  • cartilage thickness
  • RSA
  • DEXA
  • ultra sound
  • MRI
  • osteoarthritis
  • periacetabular osteotomy
03

In context

Osteoarthritis

4,398 studies on the registry are indexed under Osteoarthritis; 582 are open to participants now.

This study's enrollment of 35 is below the median of 70 across 3,440 interventional studies indexed under Osteoarthritis.

Browse Osteoarthritis studies →

Lead sponsor

University of Aarhus is the lead sponsor of 1,274 studies on the registry; 183 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 60 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Patients with radiologically diagnosed hip dysplasia (CE-angle \< 25°)
  • Patients with osteoarthritis graded 0, 1 or 2 defined according to Tönnis' classification
  • Patients with pain from hip
  • Age > 18 years
  • Minimum 110° flexion in hip joint and closed growth zones in the pelvic region
  • Informed consent

Exclusion criteria

Exclusion Criteria:

  • Patients with neurological diseases
  • Patients with calvé-Legg-Perthes syndrome
  • Patients where a femoral intertrochanteric osteotomy is necessary
  • Patients with medical sequelae after earlier hip surgery
  • Females who are pregnant
  • Patients with metal implants
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Non-randomized
Intervention model
Single group
Masking
None (open label)
Enrollment
35 participants (actual)

Study arms

  • Active comparator
    1

    Procedure: 1 Periacetabular osteotomy

Interventions

  • Procedure1 Periacetabular osteotomy

    pelvic osteotomy to increase acetabular coverage

    Also known as: periacetabular osteotomy

06

What researchers measure

Primary outcomes

  1. migration of acetabulum

    Time frame: six months

Secondary outcomes

  1. BMD in acetabulum

    Time frame: within two and a half year

  2. status of labrum

    Time frame: three years after pelvic osteotomy

  3. changes in cartilage thickness

    Time frame: two and half a year

07

Study locations

1 site
  • Orthopaedic Center, Aarhus University Hospital
    Aarhus, 8000, Denmark
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Feb 12, 2008, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00119977
Lead sponsor
University of Aarhus
First posted
Jul 14, 2005
Start date
Oct 2003
Primary completion
Dec 2007
Completion
Dec 2007
Last update
Feb 12, 2008

Study contacts

Kjeld Søballe, MD Professor
principal investigator · Orthopaedic Center, Aarhus University Hospital, Aarhus Denmark

Oversight

Data monitoring committee
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jan 2008. You cannot join it, but the record below documents what was studied.

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