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CompletedNCT00063336Updated Nov 8, 2013

Treatment Response to Rehabilitation in Patients With Schizophrenia

An interventional study of Cognitive Remediation and Computer-skills training in Schizophrenia, sponsored by Hartford Hospital. Completed at 1 site in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2013-11-08.

Sponsored by Hartford Hospital · Not applicable, Interventional, and Treatment

Phase
Not applicable
Study type
Interventional
Enrollment
46
Allocation
Randomized
Ages
18 Years and older
Sex
All
01

Study summary

This study will examine the ways in which schizophrenia-related symptoms affect response to a rehabilitation program for people with schizophrenia.

Read the detailed description

Patients with schizophrenia often suffer neurocognitive impairment and psychosocial and vocational difficulties. This study will help identify those patients most likely to benefit from existing behavioral treatments and provide clues for how to modify treatments for those who do not benefit.

Two studies will be conducted. The first will investigate the relationship of symptoms and neurocognitive variables at study entry to psychosocial and vocational status 2 years later. The second study will investigate the relationship of symptoms and neurocognitive variables at study entry to treatment response in patients assigned to either a cognitive remediation track or a computer skills track as part of their rehabilitation treatment.

Both the cognitive remediation and computer skills training programs will last 4 to 6 months. Participants will be assessed pre- and post-treatment. Neuropsychological, psychosocial and vocational status will be measured.

02

Conditions studied

  • Schizophrenia

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03

In context

Schizophrenia

3,471 studies on the registry are indexed under Schizophrenia; 472 are open to participants now.

This study's enrollment of 46 is below the median of 70 across 2,872 interventional studies indexed under Schizophrenia.

Browse Schizophrenia studies →

Lead sponsor

Hartford Hospital is the lead sponsor of 101 studies on the registry; 19 are open to participants now.

Of its 12 completed or terminated interventional studies of FDA-regulated products, 5 (42%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • DSM-IV criteria for schizophrenia or schizoaffective disorder
  • In need of intensive outpatient care
  • Treatment with atypical antipsychotic medication for a minimum of 6 months prior to study entry

Exclusion criteria

Exclusion Criteria:

  • Auditory or visual impairment
  • Mental retardation (IQ less than 70)
  • Traumatic brain injury with loss of consciousness
  • Presence or history of any neurological illness that may affect brain physiology
  • Lack of proficiency in English
  • Concurrent substance abuse and/or dependence
05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Enrollment
46 participants (actual)

Study arms

  • Experimental
    1

    Participants will receive cognitive remediation treatment.

    Behavioral: Cognitive Remediation

  • Experimental
    2

    Participants will receive computer-skills training.

    Behavioral: Computer-skills training

Interventions

  • BehavioralCognitive Remediation

    A computerized cognitive rehabilitation treatment with day-program activities

  • BehavioralComputer-skills training

    A computerized cognitive rehabilitation treatment with day-program activities

06

What researchers measure

Primary outcomes

  1. Neuropsychological test battery, including measures of visual, verbal memory, and problem-solving abilities

    Time frame: Measured pre- and post-treatment

  2. Schizophrenia symptoms

    Time frame: Measured pre- and post-treament

  3. UCSD Performance-Based Skills Assessment

    Time frame: Measured pre- and post-treatment

07

Study locations

1 site
  • Schizophrenia Rehabilitation Program, Institutes of Living
    Hartford, Connecticut 06106, United States
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Nov 8, 2013, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00063336
Lead sponsor
Hartford Hospital
Collaborators
National Institute of Mental Health (NIMH)
First posted
Jun 27, 2003
Start date
Dec 2001
Primary completion
Nov 2005
Completion
Nov 2005
Last update
Nov 8, 2013

Study contacts

Matthew M. Kurtz, PhD
principal investigator · Schizophrenia Rehabilitation Program, Institutes of Living
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in May 2009. You cannot join it, but the record below documents what was studied.

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