A Phase 1 interventional study of guanfacine in Post-Traumatic Stress Disorder, sponsored by US Department of Veterans Affairs. Completed at 1 site in United States. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2009-01-21.
Sponsored by US Department of Veterans Affairs · Phase 1, Interventional, and Treatment
This is a double-blind, placebo-controlled, randomized study lasting 8 weeks. Purpose of the study is two-fold: first, to use a pharmacological agent to treat symptoms of PTSD, and second, to explore neurobiological mechanisms of action of guanfacine.
Subject population is comprised of 100 persons with PTSD. 50 patients will receive guanfacine and 50 patients will receive a placebo. Guanfacine is prescribed at 1 mg/day and may be increased to 2 mg/day. Samples of plasma MHPG will be collected weekly. Clinical ratings of PTSD anxiety and depression, as well as vital signs, will be assessed weekly. Repeated measures analysis of variance will assess significance of main effect of drug, time, and drug by time.
1,147 studies on the registry are indexed under Stress Disorders, Traumatic; 108 are open to participants now.
Browse Stress Disorders, Traumatic studies →US Department of Veterans Affairs is the lead sponsor of 658 studies on the registry; none are open to participants now.
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This study is completed, as verified in Dec 2004. You cannot join it, but the record below documents what was studied.
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US Department of Veterans Affairs