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CompletedNCT00018187Updated Jan 21, 2009

Combinations of Pharmacologic Smoking Cessation Treatments

A Phase 1 interventional study of Bupropion and Mecamylamine in Smoking, sponsored by US Department of Veterans Affairs. Completed at 1 site in United States. Open to participants aged 20 Years to 40 Years. Per ClinicalTrials.gov, last updated 2009-01-21.

Sponsored by US Department of Veterans Affairs · Phase 1, Interventional, and Treatment

Phase
Phase 1
Study type
Interventional
Allocation
Non-randomized
Ages
20 Years to 40 Years
Sex
All
01

Study summary

The purpose of this study is to test the effectiveness of a combination of the drugs bupropion and mecamylamine along with a nicotine patch as a therapy for smoking cessation.

02

Conditions studied

  • Smoking

Keywords

  • smoking cessation
  • bupropion
  • mecamylamine
  • nicotine
03

In context

Smoking

325 studies on the registry are indexed under Smoking; 141 are open to participants now.

Browse Smoking studies →

Lead sponsor

US Department of Veterans Affairs is the lead sponsor of 675 studies on the registry; none are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
20 Years to 40 Years
Sexes eligible
All
Accepts healthy volunteers
No

Eligibility criteria

Subjects must be a smoker between 20 and 40 years old, have smoked at least 20 cigarettes per day for at least 2 years, wish to stop smoking and be in good general health

05

Study design

Phase
Phase 1
Primary purpose
Treatment
Allocation
Non-randomized
Intervention model
Single group
Masking
None (open label)

Interventions

06

Study locations

1 site
  • VA Greater Los Angeles Healthcare System
    Los Angeles, California 90073, United States
07

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jan 21, 2009, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
08

Registry details

Key details

Study ID
NCT00018187
First posted
Jul 5, 2001
Start date
Nov 1998
Completion
Jun 2001
Last update
Jan 21, 2009

Study contacts

Neil Hartman, M.D.
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in May 2007. You cannot join it, but the record below documents what was studied.

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