An observational study in Cardiovascular Diseases and Heart Diseases, sponsored by Virginia Commonwealth University. Completed. Open to male participants aged Up to 100 Years. Per ClinicalTrials.gov, last updated 2016-03-02.
Sponsored by Virginia Commonwealth University · Observational
To develop, test, and apply comprehensive mathematical models for the interaction of genetic and environmental effect on cardiovascular risk with gender differences.
DESIGN NARRATIVE:
Models were developed which allowed for sex difference in the expression of autosomal polygenes, differences in the impact of the paternal and maternal environment on male and female offspring, and for the complex consequences of assortative mating on the correlations among loci and between genes and environment. Computer simulations were used to decide which kinds of gender-dependent effects could be resolved with particular constellations of relatives, and to address problems of power and bias resulting from errors of model-specification. The methods developed were applied to data from extensive data already gathered from twins and their relatives to determine the importance of sex differences in genetic and environmental causes of variation in measured aspects of cardiovascular risk including weight, body-mass index, family history of CV disease, smoking, alcohol consumption, exercise, diet, psychosocial variables and lifestyle.
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This study is completed, as verified in Feb 2016. You cannot join it, but the record below documents what was studied.
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Virginia Commonwealth University