ClinicalTrials.gg
CompletedNCT00002069Updated Jun 24, 2005

A Study of DTC in Patients With AIDS and AIDS Related Complex

An interventional study of Ditiocarb sodium in HIV Infections, sponsored by Merieux Institute. Completed at 8 sites in United States. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2005-06-24.

Sponsored by Merieux Institute · Not applicable, Interventional, and Treatment

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Phase
Not applicable
Study type
Interventional
Ages
18 Years and older
Sex
All
01

Where this study stands

Counted across the records on this site · 2026-11-14

Among 2,802 studies in HIV Infections with a site in United States — 83 open to participants now, 140 under way, 11 of them phase 3. HIV Infections · United States.

No phase
718 of 2,802
42 open now
Registered
4th of 2,802
by date

Among the 2,802 studies in HIV Infections with a site in United States, this one is one of 718 with no phase, and was the 4th registered.

HIV Infections

4,736 studies on the registry are indexed under HIV Infections; 246 are open to participants now.

Browse HIV Infections studies →

Open to participants now

83 of the 2,802 studies in HIV Infections with a site in United States are open now. Recruiting first, the newest first:

78 more — sign in →

All 83 open studies →

A study can be open while its sites in United States have not opened yet or have stopped. Only those recruiting at a site in United States →

Who these studies take

Of the 159 HIV Infections studies recruiting now, 104 (65%) set no upper age limit and 42 (26%) stop at 75 or younger; 31 take children under 18; 60 take healthy volunteers.

This study: 18 Years and older · all sexes · no healthy volunteers.

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02

Study summary

To determine if ditiocarb sodium (sodium diethyldithiocarbamate; DTC) restores immune and host defense function; if DTC ameliorates the AIDS related complex (ARC) symptoms in patients with AIDS and ARC; if DTC prevents progression from ARC to AIDS or progression of AIDS; and if DTC prolongs survival in AIDS.

03

Conditions studied

  • HIV Infections

Keywords

  • Ditiocarb
  • Acquired Immunodeficiency Syndrome
  • AIDS-Related Complex
04

Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

Concurrent Medication:

Allowed:

  • Zidovudine (AZT).

Exclusion criteria

Exclusion Criteria

Co-existing Condition:

Patients with the following are excluded:

  • Active opportunistic infection or progressive Kaposi's sarcoma (KS).
  • Dementia.
  • Lymphoma.

Concurrent Medication:

Excluded within 3 weeks of study entry:

  • Other experimental AIDS therapy.

Patients with the following are excluded:

  • Active opportunistic infection or progressive Kaposi's sarcoma (KS).

Patients must be either seropositive or have AIDS or AIDS related complex (ARC) and have of at least 6 months.

Terms in these criteria, in plain language(2)

Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.

HIV

The human immunodeficiency virus, which weakens the immune system.

Many studies now accept people whose HIV is controlled on treatment, judged by the viral load and the CD4 count. Check the limits this study sets.

Life expectancy

The study doctor’s estimate of how long someone is likely to live. Criteria use it so that people can stay in the study long enough for it to answer its question.

05

Study design

Phase
Not applicable
Primary purpose
Treatment

Interventions

  • DrugDitiocarb sodium
06

Study locations

8 sites
  • Univ of Arizona / Arizona Cancer Ctr
    Tucson, Arizona 85724, United States
  • USC School of Medicine / Norris Cancer Hosp
    Los Angeles, California 90033, United States
  • San Francisco AIDS Clinic / San Francisco Gen Hosp
    San Francisco, California 941102859, United States
  • Portion Med Group
    Sherman Oaks, California 91403, United States
  • Florida Keys Memorial Hosp
    Key West, Florida 33040, United States
  • SUNY / Health Sciences Ctr at Brooklyn
    Brooklyn, New York 11203, United States
  • Duke Univ Med Ctr
    Durham, North Carolina 27710, United States
  • Dr Gary Brewton
    Houston, Texas 77027, United States
07

References and documents

Publications

  • Hersh EM, et al. A randomized, double-blind, placebo-controlled trial of diethyldithiocarbamate (Ditiocarb, Imuthiol(R) in patients with ARC and AIDS. Int Conf AIDS. 1990 Jun 20-23;6(3):208 (abstract no SB489)
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jun 24, 2005, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00002069
Lead sponsor
Merieux Institute
First posted
Aug 31, 2001
Last update
Jun 24, 2005
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Jul 1989. You cannot join it, but the record below documents what was studied.

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