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CompletedNCT00001782Updated Mar 4, 2008

Areas of Brain Responsible for Understanding American Sign Language

An observational study in Brain Mapping, Deafness and Healthy, sponsored by National Institute of Neurological Disorders and Stroke (NINDS). Completed at 1 site in United States. Per ClinicalTrials.gov, last updated 2008-03-04.

Sponsored by National Institute of Neurological Disorders and Stroke (NINDS) · Observational

Study type
Observational
Enrollment
30
Sex
All
01

Study summary

The human brain is made up of two halves called hemispheres. Each half of the brain is responsible for processing different kinds of information. Previous neuroimaging studies have shown that both the right and left hemispheres are involved when processing information given in American Sign Language (ASL). However, the study also showed that when processing spoken language, the left hemisphere was mostly involved.

Researchers would like to find out more about how the brain processes American Sign Language (ASL). This study is designed to determine if the right hemisphere is necessary for normal understanding of ASL.

Read the detailed description

The purpose of this protocol is to determine if the right hemisphere activation associated with perception of American Sign Language (ASL) in deaf subjects and in normal hearing individuals raised by deaf parents (who learned ASL before written English) is necessary for appropriate understanding of ASL.

02

Conditions studied

  • Brain Mapping
  • Deafness
  • Healthy

Keywords

  • Deafness
  • Hemisphere Dominance
  • Language
  • Plasticity
  • Speech
  • rTMS
03

In context

Deafness

609 studies on the registry are indexed under Deafness; 111 are open to participants now.

This study's enrollment of 30 is below the median of 80 across 168 observational studies indexed under Deafness.

Browse Deafness studies →

Lead sponsor

National Institute of Neurological Disorders and Stroke (NINDS) is the lead sponsor of 592 studies on the registry; 56 are open to participants now.

Of its 18 completed or terminated interventional studies of FDA-regulated products, 8 (44%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
All
Accepts healthy volunteers
Yes

Eligibility criteria

Subject age between 18 and 65 years.

Adult hearing offsprings of deaf parents.

Congenitally deaf individuals.

Intact hearing volunteers.

No subjects with personal or family history of seizures or other neurological or demyelinating disorders.

No pregnant women tested after urine pregnancy test.

No subjects with severe coronary disease.

No subjects with metal in the cranium except mouth.

No subjects with intracardiac lines and implanted medication pumps.

No subjects with increased intracranial pressure as evaluated by clinical means.

No subjects with cardiac pacemakers.

No subjects with an intake of neuroleptics.

05

Study design

Enrollment
30 participants
06

Study locations

1 site
  • National Institute of Neurological Disorders and Stroke (NINDS)
    Bethesda, Maryland 20892, United States
07

References and documents

Publications

  • Neville HJ, Bavelier D, Corina D, Rauschecker J, Karni A, Lalwani A, Braun A, Clark V, Jezzard P, Turner R. Cerebral organization for language in deaf and hearing subjects: biological constraints and effects of experience. Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):922-9. doi: 10.1073/pnas.95.3.922. PubMed 9448260 ↗
  • Cohen LG, Bandinelli S, Sato S, Kufta C, Hallett M. Attenuation in detection of somatosensory stimuli by transcranial magnetic stimulation. Electroencephalogr Clin Neurophysiol. 1991 Oct;81(5):366-76. doi: 10.1016/0168-5597(91)90026-t. PubMed 1718723 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Mar 4, 2008, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT00001782
Lead sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
First posted
Dec 10, 2002
Start date
Mar 1998
Completion
Dec 2000
Last update
Mar 4, 2008
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in Nov 1999. You cannot join it, but the record below documents what was studied.

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