CClinicalTrials.gg
CompletedNCT00000189Updated May 28, 2015

Gepirone vs Placebo in Treatment of Cocaine Dependence - 3

A Phase 2 interventional study of Gepirone in Cocaine-Related Disorders, sponsored by University of Pennsylvania. Completed at 1 site in United States. Open to male participants. Per ClinicalTrials.gov, last updated 2015-05-28.

Sponsored by University of Pennsylvania · Phase 2, Interventional, and Treatment

Phase
Phase 2
Study type
Interventional
Enrollment
41
Allocation
Randomized
Sex
Male
01

Study summary

The purpose of this study is to test antidepressant medication, gepirone, as a pharmacotherapy for cocaine dependent subjects.

02

Conditions studied

  • Cocaine-Related Disorders

Keywords

  • Cocaine Dependence
  • Gepirone
03

In context

Cocaine-Related Disorders

415 studies on the registry are indexed under Cocaine-Related Disorders; 12 are open to participants now.

This study's enrollment of 41 is below the median of 60 across 312 interventional studies indexed under Cocaine-Related Disorders.

Browse Cocaine-Related Disorders studies →

Lead sponsor

University of Pennsylvania is the lead sponsor of 1,635 studies on the registry; 239 are open to participants now.

Of its 154 completed or terminated interventional studies of FDA-regulated products, 104 (68%) have results posted.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
Child (0–17), Adult (18–64), Older adult (65+)
Sexes eligible
Male
Accepts healthy volunteers
No

Eligibility criteria

Please contact site for information.

05

Study design

Phase
Phase 2
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Investigator)
Enrollment
41 participants (actual)

Interventions

  • DrugGepirone
06

Study locations

1 site
  • University of Pennsylvania
    Philadelphia, Pennsylvania 19104 6178, United States
07

References and documents

Publications

  • Jenkins SW, Warfield NA, Blaine JD, Cornish J, Ling W, Rosen MI, Urschel H 3rd, Wesson D, Ziedonis D. A pilot trial of gepirone vs. placebo in the treatment of cocaine dependency. Psychopharmacol Bull. 1992;28(1):21-6. PubMed 1609038 ↗
08

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 28, 2015, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
09

Registry details

Key details

Study ID
NCT00000189
Lead sponsor
University of Pennsylvania
Collaborators
National Institute on Drug Abuse (NIDA)
Responsible party
James Cornish (Principal Investigator, University of Pennsylvania) — Principal investigator
First posted
Sep 21, 1999
Start date
Jan 1990
Primary completion
Feb 1991
Completion
Feb 1991
Last update
May 28, 2015

Study contacts

James Cornish, M.D.
principal investigator · University of Pennsylvania
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in May 2015. You cannot join it, but the record below documents what was studied.

Follow this study

Get an email when the registry record changes — status, dates, results — or when someone posts here.

Sign in to follow

Discussion

Questions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.

Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.

Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.

Start the discussion