VA Office of Research and Development: Depressive Disorder, Major trials

The registry lists 22 Depressive Disorder, Major studies with VA Office of Research and Development as lead sponsor. 7 are open to participants now and 11 have results posted.

Phase 1 2Phase 2 2Phase 3 2Phase 4 2No phase 15(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Psilocybin for Depression in VeteransNot yet recruitingNCT07895134Phase 2
• Psilocybin Intervention for Veterans Overcoming Treatment-Resistant DepressionRecruitingNCT07226232Phase 3
• Enhancing Veteran-Clinical Collaboration in VA PRRCsRecruitingNCT06898879Not applicable
• A Mobile Health Intervention to Improve Psychosocial Functioning in Veterans With Posttraumatic Stress Disorder and Depression SymptomsNot yet recruitingNCT06689787Not applicable
• Sensory Synchronized Imaging and NeuromodulationNot yet recruitingNCT06548113Not applicable
• Dosing rTMS for Depression Post-SCIRecruitingNCT05553353Not applicable
• Acceptability and Feasibility of Work-Oriented Social-Cognitive Skills Training for Veterans With Serious Mental IllnessRecruitingNCT05491538Not applicable
• A Novel Cognitive Remediation Intervention Targeting Poor Decision-making and Depression in Veterans at High Risk for Suicide: A Safe, Telehealth Approach During the COVID-19 PandemicCompletedNCT04952532Not applicableResults posted
• Comparing Individual Therapies for Veterans With Depression, PTSD, and Panic DisorderCompletedNCT04293341Not applicableResults posted
• Predicting SSRI Efficacy in Veterans With PTSDTerminatedNCT04183205Phase 4Results posted
• Comparing Group Therapies for Veterans With Depression and PTSDCompletedNCT03979040Not applicableResults posted
• A Randomized Control Trial Treating Depression With Yoga and Coherent Breathing Versus Walking in VeteransTerminatedNCT03489122Not applicableResults posted
• Ketamine for the Rapid Treatment of Major Depressive Disorder and Alcohol Use DisorderCompletedNCT02461927Phase 1/2Results posted
• Supported Employment in Patient Aligned Care TeamsCompletedNCT02400736Not applicableResults posted
• Transdiagnostic Psychotherapy for Veterans With Mood and Anxiety DisordersCompletedNCT01947647Not applicableResults posted
• Life Goals Collaborative Care to Improve Health Outcomes in Mental DisordersCompletedNCT01487668Not applicableResults posted
• VA Augmentation and Switching Treatments for Improving Depression OutcomesCompletedNCT01421342Phase 3Results posted
• The Effectiveness of rTMS in Depressed VA PatientsCompletedNCT01191333Not applicableResults posted
• Alexithymia Intervention for SuicideTerminatedNCT05724953Phase 1
• VA Aripiprazole vs Esketamine for Treatment Resistant DepressionWithdrawnNCT05554627Phase 4
• Rescuing the Ruminating Brain: Identifying Biomarkers of Rumination and Mindfulness Through Concurrent EEG and Functional Magnetic Resonance Imaging (fMRI) Studies of Schizophrenia and DepressionWithdrawnNCT03758495
• Life Goals Behavioral Change to Improve Outcomes for Veterans With Serious Mental IllnessCompletedNCT01244854Not applicable