UNC Lineberger Comprehensive Cancer Center: Head and Neck Neoplasms trials

The registry lists 20 Head and Neck Neoplasms studies with UNC Lineberger Comprehensive Cancer Center as lead sponsor. 5 are open to participants now and 7 have results posted.

Phase 1 3Phase 2 11No phase 6(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Effects of Infusion Timing on Treatment Response in Solid TumorsRecruitingNCT07630168Phase 2
• H&N NEO-COMBAT XL: Neoadjuvant XL-092 (Zanzalintinib) and Pembrolizumab (Keytruda) in Surgically Resectable, HPV Negative Oral Cavity Squamous Cell Carcinoma (OCSCC)Not yet recruitingNCT07484139Phase 2
• Sparing Parotid Ducts Via MRI Sialography for Reduced Patient-Reported XerostomiaRecruitingNCT07278557Phase 2
• Autologous CAR-T Cells Targeting CSPG4 in Relapsed/Refractory HNSCCRecruitingNCT06096038Phase 1
• Circulating Tumor DNA (ctDNA) in Locally Advanced Head and Neck Squamous Cell CarcinomaRecruitingNCT04099290
• P53 Mutational Status and cf HPV DNA for the Management of HPV-associated OPSCCCompletedNCT03077243Phase 2Results posted
• Pembrolizumab + Radiation for Locally Adv SCC of the Head and Neck (SCCHN) Not Eligible CisplatinCompletedNCT02609503Phase 2Results posted
• De-intensification of Radiation and Chemotherapy for Low-Risk HPV-related Oropharyngeal SCC: Follow-up StudyCompletedNCT02281955Phase 2Results posted
• Weekly Carboplatin, Paclitaxel and Cetuximab Treatment for Patients With Recurrent or Metastatic SCCHNCompletedNCT02124707Phase 2Results posted
• Multimodality Risk Adapted Tx Including Induction Chemo for SCCHN Amenable to Transoral SurgeryCompletedNCT01612351Phase 2Results posted
• De-intensification of Radiation & Chemotherapy in Low-Risk Human Papillomavirus-related Oropharyngeal Squamous Cell CaCompletedNCT01530997Phase 2Results posted
• Induction Chemotherapy for Locally Advanced Squamous Cell Carcinoma of the Head and NeckCompletedNCT01412229Phase 2Results posted
• Sparing Parotid Ducts Via MRI Sialography for Reduced Patient Reported XerostomiaWithdrawnNCT06276946Not applicable
• Mobile Weight Loss Intervention for Adolescent and Young Adult Cancer SurvivorsCompletedNCT06171945Not applicable
• Trial of a Personalized and Adaptive Neoantigen Dose-Adjusted Vaccine Concurrently With PembrolizumabSuspendedNCT04266730Phase 1
• Functional Sparing of Salivary Glands Using MRI Sialography for Patients Undergoing Definitive Radiation Therapy for Head and Neck Cancers of the OropharynxCompletedNCT03418792Not applicable
• Monitoring of Oral Human Papillomavirus Infection (HPV) in HPV-positive Oropharyngeal Squamous Cell Carcinoma (OPSCC)TerminatedNCT02045186Not applicable
• Finding Predictors of Side Effects to Chemoradiation Treatment in Elderly Patients With Head and Neck CancerCompletedNCT01688323
• Selective IMRT for Locally Advanced Head and Neck Carcinoma With Concurrent PanitumumabWithdrawnNCT01312493Phase 2
• Low Antioxidant Diet in Controlling Cachexia in Patients With Oropharyngeal Cancer Receiving Chemotherapy and Radiation TherapyCompletedNCT00486304Phase 1