Novartis: Hypertension trials

The registry lists 227 Hypertension studies with Novartis as lead sponsor. 4 are open to participants now and 88 have results posted.

Phase 1 18Phase 2 31Phase 3 109Phase 4 67No phase 4(a study in two phases counts in both)

Studies

Page 2 of 3. Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Study of the Efficacy and Safety of LCZ696 Alone and in Combination With Amlodipine in Patients With HypertensionWithdrawnNCT01865188Phase 3
• Double-dose Valsartan Monotherapy in Hypertension Treatment: an Effectiveness and Safety Evaluation in Chinese Patients.CompletedNCT01541189Phase 4
• Pharmacokinetics Following Single-dose of Valsartan in Japanese Pediatric PatientsCompletedNCT01447485Phase 1
• Real-world Aliskiren Use in Diabetic PatientsCompletedNCT01393860
• LFF269 Compared to Placebo After Treatment in Subjects With Essential HypertensionTerminatedNCT01373086Phase 2
• A National Multicentre Study to Assess the Efficacy of the Fixed Combination of Valsartan and Amlodipine in Hypertensive Patients Not Controlled by MonotherapyCompletedNCT01241487Phase 4
• Aliskiren in Combination With Amlodipine in Hypertensive Patients Not Responding to Angiotensin Receptor Blocker (ARB) Plus AmlodipineCompletedNCT01113047Phase 3
• Efficacy and Safety of Combination Therapy of Aliskiren/Amlodipine or Aliskiren/Amlodipine/Hydrochlorothiazide in Patients With Stage II HypertensionCompletedNCT01070030Phase 4
• A Clinical Study With Aliskiren Alone or in Combination Therapy With Diuretic Hctz in Venezuelan Hypertensive Patients.CompletedNCT01056731Phase 4
• Relative Bioavailability Study of Nadolol (1 x 80 mg) Tablets Under Fasting ConditionsCompletedNCT00960245Phase 1
• To Demonstrate the Relative Bioavailability of Atenolol Tablets, 100 mgCompletedNCT00946725Phase 1
• To Demonstrate the Relative Bioavailability Study of Ramipril 10 mg Capsules Under Non-Fasting ConditionsCompletedNCT00946621Phase 1
• To Demonstrate the Relative Bioavailability Study of Ramipril 10 mg Capsules Under Fasting ConditionsCompletedNCT00946465Phase 1
• Compare the Effect of Aliskiren Plus Valsartan Versus Angiotensin-Converting Enzyme Inhibitor (ACEi) Plus Angiotensin Receptor Blocker (ARB) [Ramipril Plus Telmisartan] on the Renin-Angiotensin-Aldosterone System (RAAS) in Hypertensive PatientsCompletedNCT00939588Phase 2
• Effect of Light Meal on Pharmacokinetic and Pharmacodynamics of Aliskiren in Patients With Mild to Moderate HypertensionCompletedNCT00933920Phase 1
• To Demonstrate the Relative Bioavailability of Atenolol TabletsCompletedNCT00913965Phase 1
• To Demonstrate the Relative Bioequivalence of Lisinopril 1 x 40 mg Tablet Under Fasting and FedCompletedNCT00883506Phase 1
• To Demonstrate the Relative Bioequivalence of Lisinopril 1 x 40 mg Tablets Under Fasting ConditionsCompletedNCT00883064Phase 1
• Comparative Bioavailability Study of Eplerenone 50 mg Tablets Under Fed ConditionsCompletedNCT00865618Phase 1
• Comparative Bioavailability Study of Eplerenone 50 mg Tablets Under Fasting ConditionsCompletedNCT00865176Phase 1
• Reducing the Overall Risk Level in Patients Suffering From Metabolic SyndromeCompletedNCT00821574Phase 4
• Proof-of-concept for the Aldosterone Synthase Inhibitor LCI699 in Patients With Primary HyperaldosteronismCompletedNCT00732771Phase 2
• Pharmacokinetic Drug Interaction Study Following Co-administration of Valsartan, Hydrochlorothiazide and Amlodipine in Patients With HypertensionCompletedNCT00548067Phase 3
• Hemodynamic Effects of Aliskiren Compared to Captopril on the Kidney in Healthy Volunteers on a Low- and High- Sodium DietCompletedNCT00518765Phase 3
• Efficacy of the New Closure Device in Improving Patient Compliance in Treatment of Hypertension With Valsartan+/-Hydrochlorothiazide (HCTZ) at 6 MonthsCompletedNCT00487123Phase 4
• Long Term Study of Valsartan and Amlodipine in Patients With Essential Hypertension (Extension to Study CVAA489A1301)CompletedNCT00446524Phase 3
• Safety and Efficacy of Valsartan Plus Hydrochlorothiazide and Amlodipine in Hypertensive PatientsCompletedNCT00426478Phase 4
• Efficacy of Valsartan/Hydrochlorothiazide Versus Amlodipine and Hydrochlorothiazide in Patients HypertensionCompletedNCT00425997Phase 4
• Pharmacokinetic and Pharmacodynamic Profiles of Aliskiren in Japanese Patients With Mild to Moderate Essential HypertensionCompletedNCT00424541Phase 1
• Effects of Lumiracoxib and Ibuprofen on Blood Pressure and Urinary Eicosanoid Excretion in Osteoarthritis Patients With Controlled HypertensionCompletedNCT00419796Phase 4
• Bioavailability of Aliskiren and Valsartan as a Single Tablet vs. the Same Doses of the Two Drugs Given Separately to Healthy Subjects.CompletedNCT00416728Phase 1
• Bioavailability of Aliskiren and Valsartan Combined as a Single Tablet vs. the Same Medications Given Separately to Healthy Subjects.CompletedNCT00416468Phase 1
• One Year Study to Evaluate the Safety of the Combination of Valsartan and Amlodipine in Patients With HypertensionCompletedNCT00409851Phase 3
• Safety and Efficacy of Valsartan and Amlodipine Combined and Alone in Patients With Hypertension.CompletedNCT00409760Phase 3
• Safety and Efficacy of Valsartan and Amlodipine Combined and Alone in Hypertensive PatientsCompletedNCT00409643Phase 3
• Efficacy and Safety of Valsartan, Hydrochlorothiazide and Amlodipine Combination Therapy in HypertensionCompletedNCT00400777Phase 4
• VALIDATE Valsartan and Supportive Measures - Impact on Drug Adherence of Treated Hypertensive PatientsCompletedNCT00394823Phase 3
• Effect of Valsartan on Lipid Subfractions in Hypertensive Patients With Metabolic SyndromeCompletedNCT00394745Phase 3
• A Study to Evaluate the Combination of Valsartan + Amlodipine in Hypertensive PatientsCompletedNCT00392262Phase 3
• Safety/Efficacy of Combo Therapy With Aliskiren & Hydrochlorothiazide vs Therapy With Hydrochlorothiazide Alone in Patients With HypertensionCompletedNCT00387517Phase 3
• A Safety and Efficacy Trial of the Combination of Aliskiren / Hydrochlorothiazide (HCTZ)(300/12.5 mg and 300/25 mg) Compared to Aliskiren 300 mg in Hypertensive PatientsCompletedNCT00386139Phase 3
• Efficacy and Safety of Valsartan and the Combination of Valsartan and SimvastatinCompletedNCT00385931Phase 3
• Clevidipine in the Treatment of Patients With Severe Hypertension (VELOCITY)CompletedNCT00369837Phase 3
• Effects of Amlodipine/Benazepril in the Hypertensive African-American Population With Type 2 Diabetes MellitusCompletedNCT00367978Phase 4
• Efficacy and Safety of the Combination of Valsartan Plus Amlodipine in Hypertensive Patients Not Adequately Responding to the Combination Therapy With Ramipril Plus FelodipineCompletedNCT00367939Phase 3
• Combination of Benazepril Plus Hydrochlorothiazide in Chinese Patients With Mild to Moderate Essential HypertensionCompletedNCT00367094Phase 3
• Efficacy and Safety of Valsartan Plus Hydrochlorothiazide in Fixed Dose Combination in Hypertensive Patients Not Controlled by the Free Combination of an Angiotensin Receptor Blocker Plus HydrochlorothiazideCompletedNCT00360178Phase 3
• Efficacy & Safety of Orally Administered Valsartan/Amlodipine Combo Therapy vs Amlodipine Monotherapy in Black Patients With Stage II HypertensionCompletedNCT00353912Phase 3
• Effectiveness of a Valsartan Based vs an Amlodipine Based Treatment Strategy in naïve Patients With Stage 1 or Stage 2 Hypertension or in Patients Uncontrolled on Current MonotherapyCompletedNCT00351130Phase 4
• Efficacy & Safety of Orally Administered Valsartan/Amlodipine Combo Therapy vs Amlodipine Monotherapy in Patients With Stage II HypertensionCompletedNCT00350168Phase 3
• Study Comparing SPP100 (Aliskiren) 150mg to Placebo and to Losartan 50mg in Patients With Mild to Moderate Essential HypertensionCompletedNCT00344110Phase 3
• Efficacy and Safety of Aliskiren 300mg Compared to Irbesartan 300mg and Ramipril 10 mg in the Setting of a Missed Dose for Patients With Essential Hypertension.CompletedNCT00343551Phase 3
• Long Term Study of VAH631 in Patients With Essential Hypertension (Extension From B1303 Study)CompletedNCT00338936Phase 3
• Comparative Study of Valsartan and Amlodipine Versus Amlodipine Alone in HypertensionCompletedNCT00333489Phase 4
• 8-week Study to Evaluate Safety and Efficacy of Various Combinations of Valsartan, HCTZ, and Amlodipine in Patients With Moderate to Severe HypertensionCompletedNCT00327587Phase 3
• A Study to Evaluate the Combination of Valsartan and Amlodipine in Hypertensive Patients Not Controlled on MonotherapyCompletedNCT00327145Phase 3
• A Study of VAH631 in Patients With Essential Hypertension (Factorial Study)CompletedNCT00311740Phase 3
• SPP100 Dose Finding Study in JapanCompletedNCT00311012Phase 2
• Effectiveness of a Valsartan Based Versus an Amlodipine Based Treatment Strategy in naïve Patients With Stage 1 or Stage 2 Hypertension or in Patients Uncontrolled on Current MonotherapyCompletedNCT00304226Phase 4
• SPP100 (Aliskiren) Regimen in Hypertensive Patients With Renal DysfunctionCompletedNCT00299832Phase 3
• SPP100 (Aliskiren) Regimen in Patients With Severe HypertensionCompletedNCT00299806Phase 3
• A Clinical Study to Compare Long-term Efficacy and Safety of an Aliskiren Based Regimen to a Hydrochlorothiazide Based Treatment Regimen With Optional Addition of AmlodipineCompletedNCT00294710Phase 3
• Efficacy and Safety of Valsartan/Hydrochlorothiazide Combination Therapy in Patients With HypertensionCompletedNCT00280540Phase 4
• Efficacy and Safety of Valsartan/Hydrochlorothiazide Combination Therapy in Patients With HypertensionCompletedNCT00277472Phase 4
• Valsartan/Hydrochlorothiazide Combination in the Treatment of Severe HypertensionCompletedNCT00273299Phase 3
• Safety and Efficacy of Lumiracoxib in Patients With Osteoarthritis and With Controlled HypertensionCompletedNCT00267176Phase 4
• Efficacy and Safety of Aliskiren and Atenolol in Adults (>18) With Mild to Moderate HypertensionCompletedNCT00262236Phase 3
• A Dose Ranging Study to Compare the Safety and Efficacy of Aliskiren in Patients With High Blood PressureCompletedNCT00260923Phase 3
• A Study to Evaluate the Efficacy of Valsartan/Simvastatin Combinations in Patients With Both Essential Hypertension and HypercholesterolemiaCompletedNCT00254475Phase 3
• A Study in Chinese Mild to Moderate Hypertensive Patients Comparing the Efficacy of Co-Diovan With Diovan.CompletedNCT00250562Phase 3
• A Long Term Study of SPP100 in Patients With Essential Hypertension (Trial is Not Recruiting in the US)CompletedNCT00246584Phase 2
• Diva - The Effects Of 12 Weeks Of Treatment With High Dose Valsartan (320 Mg) To Amlodipine On Endothelial Function In Hypertensive Subjects With The Metabolic SyndromeCompletedNCT00241150Phase 4
• A Study to Compare Treating Hypertension With Valsartan 160 MG to Valsartan 320 MgCompletedNCT00241137Phase 3
• Comparison Of Morning And Evening Dosing Of Valsartan And Lisinopril In Patients With DiabetesCompletedNCT00241124Phase 4
• The VALIDATE Study of Valsartan for Patients With Early Stage Heart FailureCompletedNCT00241098Phase 4
• Effect of Valsartan on Proteinuria in Patients With Hypertension and Diabetes MellitusCompletedNCT00241085Phase 4
• Clinical Trial To Evaluate The Effect Of Valsartan On Insulin Sensitivity In Subjects With Impaired Glucose ToleranceCompletedNCT00241072Phase 4
• A Study Comparing Valsartan With And Without Hydrochlorothiazide In Patients With HypertensionCompletedNCT00241007Phase 3
• A Clinical Study to Evaluate the Safety and Efficacy of the Combination of Aliskiren and Valsartan in Hypertensive Non Responders PatientsCompletedNCT00219193Phase 3
• Clinical Study to Evaluate Efficacy and Safety of Aliskiren (150mg & 300mg) Administered Alone and in Combo With Valsartan (160mg and 320mg) in Patients With High Blood PressureCompletedNCT00219180Phase 3
• A Clinical Study to Assess Efficacy and Safety of Aliskiren in the Elderly With High Blood PressureCompletedNCT00219167Phase 3
• A Clinical Study to Compare Long-term Efficacy and Safety of an Aliskiren Based Regimen to a Hydrochlorothiazidebased Treatment Regimen With Optional Addition of AmlodipineCompletedNCT00219154Phase 3
• A Dose Ranging Study to Compare the Safety and Efficacy of Aliskiren 150mg, 300mg, and 600mg to Placebo in Patients With High Blood Pressure.CompletedNCT00219128Phase 3
• A Clinical Study to Compare Combination of Aliskiren+ HCTZ to Irbesartan+ HCTZ or Amlodipine+ HCTZ or HCTZ Alone in Obese Hypertensive Not Responsive to HCTZ 25 mgCompletedNCT00219115Phase 3
• A Clinical Study to Evaluate Safety & Efficacy of the Combination of Aliskiren, Valsartan & Hydrochlorothiazide in Diabetic Hypertensive Nonresponder PatientsCompletedNCT00219102Phase 3
• A Clinical Study to Evaluate the Safety and Efficacy of Aliskiren Alone and in Combination With Ramipril in Hypertensive, Diabetic Patients.CompletedNCT00219089Phase 3
• A Clinical Study to Evaluate the Safety and Efficacy of the Combination of Aliskiren and Amlodipine in Hypertensive Non Responders PatientsCompletedNCT00219076Phase 3
• A Clinical Study to Compare an Aliskiren Based Hypertensive Regimen With a Ramipril Based One Followed by a Randomized Withdrawal.CompletedNCT00219063Phase 3
• A Clinical Study to Compare the Safety and Efficacy of an Aliskiren-based Regimen With a Lisinopril Based Regimen in Patients With Severe HypertensionCompletedNCT00219050Phase 3
• Long Term Safety of Aliskiren Alone or With the Optional Addition of Hydrochlorothiazide in Patients With Essential HypertensionCompletedNCT00219037Phase 3
• Clinical Study to Evaluate the Efficacy and Safety of Aliskiren Alone and in Combination With Hydrochlorothiazide in Patients With Essential Hypertension.CompletedNCT00219024Phase 3
• "ALOFT - Aliskiren Observation of Heart Failure Treatment": Efficacy and Safety of Aliskiren Added on Top of Standard Therapy in Adults (≥ 18 Years) With Stable Heart FailureCompletedNCT00219011Phase 3
• Hypertension and Cardiovascular Risk FactorsCompletedNCT00171782Phase 4
• Study to Compare the Effect of Valsartan vs Atenolol on Pro-thrombotic State in Hypertensive Patients.CompletedNCT00171756Phase 4
• Antialbuminuric Effects of Valsartan and LisinoprilTerminatedNCT00171600Phase 4
• Antiproteinuric Effect of Valsartan and LisinoprilCompletedNCT00171574Phase 4
• Valsartan/Hydrochlorothiazide Combination vs Amlodipine in Patients With Hypertension, Diabetes, and Albuminuria.CompletedNCT00171561Phase 4
• Efficacy and Safety of Valsartan/Amlodipine Combination in Patients With Severe HypertensionCompletedNCT00171535Phase 3
• Comparison of Two Treatment Strategies in Hypertensive PatientsCompletedNCT00171444Phase 4
• A Clinical Study to Evaluate the Long-term Safety (12 Months) of the Combination of Aliskiren 300 mg and Hydrochlorothiazide 25 mgCompletedNCT00171405Phase 3